Overview

Zinc Finger Proteins is the first book to systematically assemble knowledge of various zinc finger proteins belonging to several families and to describe features of zinc finger proteins at levels ranging from atomic to cellular and to organismal. Significance of zinc itself is also addressed as are important domains often associated with zinc fingers. This book is an ideal resource for students who want to learn about zinc finger proteins as well as for scientists who work on gene expression, signal transduction, differentiation, development, cancer and neurological diseases.

Full Product Details

Author:   Shiro Iuchi ,  Natalie Kuldell, PhD
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2005
Dimensions:   Width: 21.00cm , Height: 1.50cm , Length: 28.00cm
Weight:   0.736kg
ISBN:  

9781441934345

ISBN 10:   1441934340
Pages:   276
Publication Date:   23 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account.- The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account.- Binding of Zinc Fingers to DNA.- C2H2 Zinc Fingers As DNA Binding Domains.- TFIIIA: A Sophisticated Zinc Finger Protein.- GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction.- The DNA-Binding Domain of GATA Transcription Factors—A Prototypical Type IV Cys2-Cys2 Zinc Finger.- MutM: Single C2C2 Zinc Finger-DNA Interaction.- Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function.- Zinc Finger Interactions with Metals and Other Small Molecules.- Synthetic Zinc Finger Transcription Factors.- Binding of Zinc Fingers to RNA.- TFIIIA and p43: Binding to 5S Ribosomal RNA.- RNA Binding by Single Zinc Fingers.- Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA.- Tandem CCCH Zinc Finger Proteins in mRNA Binding.- Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a.- Binding of Zinc Fingers to Proteins.- LIM Domain and Its Binding to Target Proteins.- RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation.- Structure and Function of the CBP/p300 TAZ Domains.- A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2.- Binding of Zinc Fingers to Small Molecules.- The FYVE Finger: A Phosphoinositide Binding Domain.- Common Domains Present in Zinc Finger Proteins.- The BTB Domain Zinc Finger Proteins.- KRAB Zinc Finger Proteins: A Family of Repressors Mediating Heterochromatin-Associated Gene Silencing.- The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors.- Biology ofZinc Finger Proteins.- Sp1 and Huntington’s Disease.- The Role of WT1 in Development and Disease.- Yin Yang 1.- The Multiple Cellular Functions of TFIIIA.- The Role of the Ikaros Gene Family in Lymphocyte Development.- Basonuclin: A Zinc Finger Protein of Epithelial Cells and Reproductive Germ Cells.- ZAS Zinc Finger Proteins: The Other ?B-Binding Protein Family.- Role of GATA Factors in Development.- The Androgen Receptor and Spinal and Bulbar Muscular Atrophy.- The Role of XPA in DNA Repair.- MOF, an Acetyl Transferase Involved in Dosage Compensation in Drosophila, Uses a CCHC Finger for Substrate Recognition.- MDM2: RING Finger Protein and Regulator of p53.- Biology of Zinc Ion.- The Zip Family of Zinc Transporters.- Apoptosis by Zinc Deficiency.

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