Overview

The use of animals as a source of cells, tissues, and organs for transplantation - xenotransplantation - has been of increasing interest in recent years. Transplantation of animal tissues into human patients is occurring now at various centers and the possibility of organ xenotransplants is widely discussed. This new volume presents a balanced review of recent progress in understanding the immunologic aspects of xenotransplantation and zoonotic risks. It addresses how the application of various immunosuppressive modalities might compromise the immunological competence of recipients and examines the relevant issues relating to zoonotic disease. This is the first book to deal with the issues of host defense and zoonosis in xenotransplantation and points to the critical issues that must be addressed to make the process safe from the perspective of the patient and society as well as critical questions yet to be answered.

Full Product Details

Author:   Jeffrey L Platt
Publisher:   American Society for Microbiology
Imprint:   American Society for Microbiology
Dimensions:   Width: 25.40cm , Height: 2.00cm , Length: 17.80cm
Weight:   0.726kg
ISBN:  

9781555811679

ISBN 10:   1555811671
Pages:   308
Publication Date:   27 December 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Unknown
Availability:   Out of stock  

Table of Contents

INTRODUCTION 1. A Primer on Xenotransplantation (Jeffrey L. Platt) 2. Coming to Terms with Reality: Why Xenotransplantation Is a Necessity (Roger W. Evans) IMMUNOLOGICAL HURDLES TO XENOTRANSPLANTATION 3. The Complement System as a Hurdle to Xenotransplantation (Agustin P. Dalmasso) 4. NK Cells as a Barrier to Xenotransplantation (Thierry Berney, Antonello Pileggi, and Luca Inverardi) 5. Cellular Immune Responses to Xenografts (Ronald G. Gill) 6. Therapeutic Strategies for Xenotransplantation (L. Buhler, M. R. Basker, I. P. J. Alwayn, D. H. Sachs, and D. K. C. Cooper) IMPACT OF THERAPEUTIC MANIPULATIONS ON HOST RESPONSE TO INFECTION 7. Manipulation of the Humoral Immune System and the Host Immune Response to Infection (Eric Wagner and Michael M. Frank) 8. Complement Regulation and the Host Response to Infection (B. Paul Morgan) 9. Recognition of Foreign Antigen and Foreign Major Histocompatibility Complex (Adriana Colovai, Rodica Ciubotariu, Raffaello Cortesini, and Nicole Suciu-Foca) ZOONOSIS IN XENOTRANSPLANTATION 10. Xenotransplantation as a Vector for Infection (Marian G. Michaels) 11. Zoonosis as a Risk to the Xenograft Recipient and to Society: Theoretical Issues (Louisa E. Chapman) 12. Zoonotic Agents in Swine-to-Human Xenotransplants (Peter J. Matthews) 13. Retroviruses and Xenotransplantation (Robin A. Weiss) 14. Potential Medical Impact of Endogenous Retroviruses (Rima Abu-Nader and Carlos V. Paya) 15. Prevention of Infection in Xenotransplantation (Jay A. Fishman)

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