Overview

This new edition of What's Wrong With My Mouse? continues to provide the most thorough overview of mutant mouse technology and a readable introduction to the field of behavioural neuroscience as applied to behavioural phenotyping of transgenic and knockout mice. Written in the same engaging, lively manner that is a trademark of the first edition, it has been fully updated to reflect the latest advances, from widespread use of conditional promoters and inducible systems to the applications of micro arrays and proteomics. It also addresses the rapid developments in gene delivery technology, rescue techniques, stem cell transplantation, and knockdown and knock-in approaches. It discusses the many exciting new-targeted gene mutation models of human diseases that have been adopted by pharmaceutical companies for molecular screening and drug discovery research.

New to the Second Edition: A chapter on Developmental and Neurodegenerative Diseases, covering mental retardation and inborn errors of metabolism through to Alzheimer's disease and stroke Practical recommendations for choosing tasks to evaluate a new mutant line, including complete guidelines for high-throughput screening Expanded discussion of the latest studies in learning and memory, autism and social phobias, olfaction, drug addiction, withdrawal, and spinal cord injury Numerous figures showing new behavioural tests, equipment, and data

From the reviews of the First Edition:

this valuable book...is a must have and must read book for anyone planning to enter the field of mouse behavioral analysis. GENES, BRAIN AND BEHAVIOR

I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent loan to their students, post-doctoral students and colleagues in molecular biology. TRENDS IN PHARMACOLOGICAL SCIENCES

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