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OverviewThe goal of this book is to explore the complexity of a microscopic bit of matter that exists in a myriad of copies within our bodies, the voltage-sensitive ion channel. We seek to investigate the way in which these macromolecules make it possible for the long fibers of our nerve and muscle cells to conduct impulses. These integral components of cell membranes are marvels of nature's evolutionary adaptation. To understand them we must probe the boundaries of physics and chemistry. Since function is intimately related to structure, we examine the molecular structure of channels, focusing on physical principles that govern all matter. With the application of genetic methods, our knowledge of ion channels has broadened and deepened. In the hope that research can help ameliorate suffering, we discuss the diseases that arise from channel malfunctions due to genetic mutations. This book is intended for students and scientists who are willing to travel into uncharted waters of an interdisciplinary science. We approach the subject of volta- sensitive ion channels from various points of view. This book seeks to give voice to the viewpoints of the physical and the biological scientist, and to bridge gaps in terminology and background. Readers may find this book to have both elementary and advanced aspects: For the reader trained in the biological sciences, it reviews background in physics and chemistry; for the reader trained in the physical sciences, it reviews background in physiology and biochemistry. Full Product DetailsAuthor: H. Richard LeuchtagPublisher: Springer Imprint: Springer Edition: Softcover reprint of hardcover 1st ed. 2008 Dimensions: Width: 15.50cm , Height: 2.80cm , Length: 23.50cm Weight: 0.842kg ISBN: 9789048173846ISBN 10: 9048173841 Pages: 532 Publication Date: 19 October 2010 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of print, replaced by POD  We will order this item for you from a manufatured on demand supplier. Table of ContentsExploring Excitability.- Information In The Living Body.- Animal Electricity.- Electrophysiology Of The Axon.- Aspects Of Condensed Matter.- Ions In The Electric Field.- Ions Drift And Diffuse.- Multi-Ion And Transient Electrodiffusion.- Models Of Membrane Excitability.- Admittance To The Semicircle.- What's That Noise?.- Ion Channels, Proteins And Transitions.- Diversity And Structures Of Ion Channels.- Microscopic Models Of Channel Function.- Order From Disorder.- Polar Phases.- Delicate Phases And Their Transitions.- Propagation And Percolation In A Channel.- Screws And Helices.- Voltage-Induced Gating Of Ion Channels.- Branching Out.ReviewsFrom the reviews: ...this well-written and thoroughly researched book is Dr. Leuchtag's crowning achievement as it presents ion channel structure and function painted on a broad canvass of biological, physical and mathematical backdrop that is needed to properly understand these small yet hugely important biological switches. Prof. Jack Tuszynski: Allard Research Chair Division of Experimental Oncology, Room 3336, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2 Canada ! This book is an impressive sum of more than 500 pages dealing with conventional as well as unconventional views on excitability and channels with some historic remainders on animal electricity and general considerations on 'information in the living body' including primitive forms such as bacteria swimming! Professor Leuchtag's book is well written, easy to read, despite necessary theoretical disgressions, resulting in a real interdisciplinary account (even sometimes thought-provoking) of what is presently known about voltage-sensitive ion channels and molecular excitability. Herve Duclohier is in the Physiopathology and Pharmacology of Ion Channels Group, UMR 6187-Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 POITIERS (France). E-mail : Herve.Duclohier@univ-poitiers.fr ! Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics! The book is very well referenced!and is a challenge for physicists and biologists alike!Experts in both fields, as well as young graduates will certainly benefit from the vast amount of information collected; moreover, they may be motivated for an exciting journey to living matter from a physical perspective. Alexander G. Petrov, PhD, DSc, FBAS, Director, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia From the reviews: ...this well-written and thoroughly researched book is Dr. Leuchtag's crowning achievement as it presents ion channel structure and function painted on a broad canvass of biological, physical and mathematical backdrop that is needed to properly understand these small yet hugely important biological switches. Prof. Jack Tuszynski: Allard Research Chair Division of Experimental Oncology, Room 3336, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2 Canada ... This book is an impressive sum of more than 500 pages dealing with conventional as well as unconventional views on excitability and channels with some historic remainders on animal electricity and general considerations on 'information in the living body' including primitive forms such as bacteria swimming... Professor Leuchtag's book is well written, easy to read, despite necessary theoretical disgressions, resulting in a real interdisciplinary account (even sometimes thought-provoking) of what is presently known about voltage-sensitive ion channels and molecular excitability. Herve Duclohier is in the Physiopathology and Pharmacology of Ion Channels Group, UMR 6187-Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 POITIERS (France). E-mail : Herve.Duclohier@univ-poitiers.fr ... Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics... The book is very well referenced...and is a challenge for physicists and biologists alike...Experts in both fields, as well as young graduates will certainly benefit from the vast amount of information collected; moreover, they may be motivated for an exciting journey to living matter from a physical perspective. Alexander G. Petrov, PhD, DSc, FBAS, Director, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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