Overview

"Uvelichenie rasprostranennosti khronicheskikh zabolevaniy i raznoobrazie klinicheskikh variantov ikh techeniya prinyato ob""yasnyat' plokhoy ekologiey, stressami, izmeneniem obraza zhizni i drugimi faktorami vneshney sredy. Odnako mul'tifaktorial'nye zabolevaniya yavlyayutsya boleznyami s nasledstvennoy sostavlyayushchey, i izmeneniya v ikh rasprostranennosti i strukture zavisyat ot geneticheskikh faktorov. Nami izuchalos' vliyanie geneticheskikh faktorov - nasledovaniya, otbora i autbridinga - na rasprostranennost' i evolyutsiyu mul'tifaktorial'nykh zabolevaniy. Issledovalis' sleduyushchie patologii: sakharnyy diabet, metabolicheskiy sindrom, diffuzno-toksicheskiy i uzlovoy zob, rak shchitovidnoy zhelezy. Pokazano, chto dinamiku rasprostranennosti bolezni v populyatsii opredelyayut otbor v sochetanii s kharakterom nasledovaniya zabolevaniya: napravlennost' izmeneniy opredelyaet otbor, a masshtabnost' - tip nasledovaniya. Polozhitel'naya napravlennost' otbora poligennykh zabolevaniy sposobstvuet poyavleniyu novykh klinicheskikh form bolezni i uvelichivaet v strukture patologii dolyu klinicheskikh variantov techeniya s bol'shey nasledstvennoy otyagoshchennost'yu. Dlya genetikov, endokrinologov, vrachey, antropologov, studentov-medikov i biologov."

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