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OverviewThis volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike. Full Product DetailsAuthor: Eric Hunter , Klaus BisterPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 1st ed. 2017 Volume: 407 Weight: 4.794kg ISBN: 9783319618036ISBN 10: 3319618032 Pages: 221 Publication Date: 06 September 2017 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsExchange of Genetic Sequences Between Viruses and Host.- Virus-Host Gene Interactions that Define HIV Disease Progression.- Sequencing the Biology of Entry: The Retroviral env Gene.- Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases.- MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.- Oncogenic Roles of the PI3K/AKT/mTOR Axis.- MicroRNAs and Cancer.- The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene.ReviewsAuthor InformationEric Hunter, PhD, is a Professor of Pathology and Laboratory Medicine and a Georgia Research Alliance Eminent Scholar, based in Atlanta, GA, USA Klaus Bister, PhD, is a Professor Emeritus of Biochemistry of University of Innsbruck, Austria, and a Professor Adjunct of The Scripps Research Institute, La Jolla, CA, USA Tab Content 6Author Website:Countries AvailableAll regions |
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