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OverviewCurrently,there is no single source that permitscomparisonof the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our parti- lar system,missing outon theopportunityto de neunifyingthemesin viralgenome replication or bene t from the advances in other systems. For example, extraor- nary biologicaland experimentalparadigmsthat have been established overthe past 5 years for the DNA replication systems of bacteriophage T4 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the eld, as well as encourage students into this area of research. The monograph has been divided into eight parts. Chapters appearing in Parts I-VI are intended to compare and contrast the replication and/or transcription processes and corresponding ""players"" of the indicated family of viruses. We are interested in the sequence of events that lead to production of mRNA and progeny genomes as well as the cis-acting elements and trans-acting factors and enzymes (viral and cellular) that are required for these processes. Chapters appearing in Part VII are - tended to providea more biochemical and biophysicalperspective of the replication and/ortranscriptionprocess. Chaptersappearingin Part VIII are intendedto provide a practical perspective on viral replication and its inhibition. Full Product DetailsAuthor: Craig E. Cameron , Matthias Gotte , Kevin RaneyPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2009 ed. Dimensions: Width: 15.50cm , Height: 3.40cm , Length: 23.50cm Weight: 1.259kg ISBN: 9780387894256ISBN 10: 038789425 Pages: 636 Publication Date: 21 July 2009 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsGenome replication strategies.- Model of Picornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C Virus Genome Replication.- Brome Mosaic Virus RNA Replication and Transcription.- Retroviruses.- Hepadnaviral Genomic Replication.- Rhabdoviruses.- Orthomyxovirus Genome Transcription and Replication.- Arenaviruses: Genome Replication Strategies.- Core-Associated Genome Replication Mechanisms of dsRNA Viruses.- Poxviruses.- Herpesvirus Genome Replication.- Host Factors Promoting Viral RNA Replication.- Host Factors that Restrict Retrovirus Replication.- Elements, factors and enzymes: Structure-function and mechanism.- T4 Phage Replisome.- Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase.- RNA Virus Polymerases.- Human Immunodeficiency Virus Reverse Transcriptase.- Viral Helicases.- Integrase: Structure, Function, and Mechanism.- Antivirals: Targets, mechanisms and resistance.- Viral DNA Polymerase Inhibitors.- Viral RNA Polymerase Inhibitors.- HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance.- Lethal Mutagenesis.- Clinical Implications of Reverse Transcriptase Inhibitor Resistance.ReviewsFrom the reviews: Viruses are primarily classified by the structure of their genomes. ... they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ... the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ... I recommend this title to all those interested in viral replication. (Christopher Ring, Microbiology Today, November, 2009) From the reviews: Viruses are primarily classified by the structure of their genomes. ... they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ... the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ... I recommend this title to all those interested in viral replication. (Christopher Ring, Microbiology Today, November, 2009) From the reviews: Viruses are primarily classified by the structure of their genomes. ... they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ... the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ... I recommend this title to all those interested in viral replication. (Christopher Ring, Microbiology Today, November, 2009) From the reviews: Viruses are primarily classified by the structure of their genomes. ! they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ! the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ! I recommend this title to all those interested in viral replication. (Christopher Ring, Microbiology Today, November, 2009) Author InformationTab Content 6Author Website:Countries AvailableAll regions |