Overview

The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA.

Full Product Details

Author:   Chris R. Calladine (Dept. of Engineering, University of Cambridge, U.K.) ,  Horace Drew (CSIRO Division of Biotechnology, Sydney, Australia) ,  Ben Luisi (Department of Biochemistry, University of Cambridge, U.K.) ,  Andrew Travers (MRC Laboratory of Molecular Biology, University of Cambridge, U.K.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   3rd edition
Dimensions:   Width: 17.10cm , Height: 2.10cm , Length: 24.40cm
Weight:   0.860kg
ISBN:  

9780121550899

ISBN 10:   0121550893
Pages:   352
Publication Date:   13 March 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

An Introduction to Molecular Biology for Non-Scientists Why a Helix? Different Kinds of Double Helix Twisting and Curving Curving in Three Dimensions DNA Supercoiling The Assembly of DNA intor Chromosomes Specific DNA-Protein Interactions Methods Used to Study the Structure of DNA DNA in Disease, Diagnostics and Medicine Cytosine Methylation and DNA Epigenetics Appendix 1: Notes on the Derivation of Some Technical Terms 2: The Chemical Theory of Base-stacking Interactions in DNA 3: How to modify Gene Expression by means of Anti-sense Oligonucleotides, Ribozymes or si-RNA

Reviews

Praise for previous editions: Stylish...beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit and which will also generate a refreshing perspective for experts -NATURE Understanding DNA is a great book that will surely prove to be a valuable teaching tool. -THE BIOCHEMIST A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective. -TRENDS IN GENETICS

Author Information

Chris Calladine is Professor of Structural Mechanics at the University of Cambridge. In addition to researching aspects of structural engineering, he has applied the methods of structural mechanics to the study of flagella and DNA. Horace Drew solved several of the first DNA crystal X-ray structures with Richard Dickerson at Caltech, and subsequently spent five years researching DNA and chromosome structures with Aaron Klug at the MRC Laboratory of Molecular Biology in Cambridge, UK He now lives in Australia and is a Principle Research Scientist at the CSIRO Division of Biomolecular Engineering in Sydney.

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