Overview

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recent years, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body - indeed affecting both psychological and physical health. This book brings together world leaders in research on depression, to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psychological, genetic and evolutionary models, with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore linking depression to physical health. Opening with a powerful, personal, account of depression, that conveys something of the all-consuming, debilitating, nature of this illness, the book then presents cutting edge research from those at the frontiers of work in this area. The book will be valuable for all psychiatrists, clinical psychologists and neuroscientists seeking a state-of-the-art of this global problem

Full Product Details

Author:   Carmine Pariante (Institute of Psychiatry) ,  Randolph M. Nesse (University of Michigan) ,  David Nutt (University of Bristol) ,  Lewis Wolpert (University College London)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 17.20cm , Height: 2.20cm , Length: 24.60cm
Weight:   0.714kg
ISBN:  

9780199533077

ISBN 10:   0199533075
Pages:   400
Publication Date:   02 July 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

1: Lewis Wolpert: Experiencing depression 2: Monica Kelly Cowles, Carmine Pariante & Charles B Nemeroff: Depression in the medically ill 3: Randolph M Nesse: Explaining depression: neuroscience is not enough, evolution is essential 4: Bernard J Crespi: Evolutionary genetics of affective disorders 5: Stephan Claes, Elisabeth B Binder & Charles B Nemeroff: Genetic factors in stress and major depression 6: Daniel J Smith, Michael J Owen & Nick Craddock: Bipolar disorder and unipolar depression: what is the genetic relationship? 7: Becky Conway-Campbell, C C Wiles & Stafford Lightman: The significance of dysregulated basal glucocorticoid pulsatility in affective disorders 8: Caitlin S Wyrwoll, Megan C Holmes & Jonathan R Seckl: Early life programming of affective function 9: Sabine Chourbaji & Peter Gass: Modeling depression by GR mutant animals? 10: Robert Dantzer, Jason C O'Connor, Nathalie Castanon, Jacques Lestage & Keith W Kelley: Cytokines and depression: experimental evidence and intermediate mechanisms 11: Paul Lucassen, Peter Meerlo, A S Naylor, A M van Dam, A G Dayer, B Czeh & C A Oomen: Do depression, stress, sleep disruption and inflammation alter hippocampal apoptosis and neurogenesis? 12: Steven F Maier, Jose Amat, Michael V Baratta, Sondra T Bland, John C Christianson, Brittany Thompson, Robert R Rozeske & Linda R Watkins: The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events 13: Philip J Cowen & C J Harmer: Is it all monoamines? 14: Nicole Geschwind, Jim van Os, Frenk Peeters & Marieke Wichers: The role of affective processing in vulnerability to and resilience against depression 15: Elizabeth Young: PTSD and HPA axis: same hormones, different disorders 16: Timothy G Dinan & Peter Fitzgerald: Neuroendocrine and immune cross talk in major depression 17: Andrew H Miller, Thaddeus W W Pace & Charles I Raison: Neuropsychiatric effects of IFN-alpha: relevance to depression 18: Andrew Steptoe: Depression and coronary heart disease 19: Tony Cleare: Does depression induce pain and fatigue? 20: Matthew Hotopf & Max Henderson: Explaining the association between depression and mortality: a life course epidemiology approach 21: Allan H Young: Depression: unipolar or bipolar, what's the difference (and what does it matter anyway)? 22: Matthew T Keener & Mary L Phillips: Can neuroimaging help distinguish bipolar depression from major depressive disorder? 23: Bhanu Gupta, Robert Keers, Rudolf Uher, Peter McGuffin & Katherine J Aitchison: Pharmacogenetics of antidepressant response 24: R Hamish McAllister-Williams & Grzegorz Wisniewski: Can the EEG be used to predict antidepressant response? 25: Thomas E Schlaepfer & Bettina Bewernick: Can we use magnetic/electric fields to help in treatment resistant depression? 26: Sarah E Gartside, K S Reid & I Nicol Ferrier: Antiglucocorticoids in the treatment of affective disorders: from pre-clinical to clinical studies 27: David Nutt & Christoher A Lowry: How can we use current knowledge to improve antidepressant treatments?

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