Overview

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.

Full Product Details

Author:   Dmitry I. Gabrilovich ,  Arthur Andrew Hurwitz
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 2nd ed. 2014
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   7.197kg
ISBN:  

9781493950515

ISBN 10:   1493950517
Pages:   464
Publication Date:   27 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface.- Regulatory T Cells and Cancer.- Th17 cells in cancer.- Mast cells and immune response in cancer.- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance.- Immunobiology of Dendritic Cells in Cancer.- Macrophages and Tumor Development.- Angiogenesis and Immune Suppression in Cancer.- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment.- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer.- IDO in Inflammatory Programming and Immune Suppression in Cancer.- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity.- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment.- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer.- Index.

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