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OverviewThe growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity. The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities. Full Product DetailsAuthor: Yona KeisariPublisher: Springer Imprint: Springer Edition: 2013 ed. Volume: 5 Dimensions: Width: 15.50cm , Height: 0.90cm , Length: 23.50cm Weight: 2.642kg ISBN: 9789400799325ISBN 10: 9400799322 Pages: 156 Publication Date: 21 September 2014 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPreface.-1 Effect of chemotherapy on the tumor microenvironment and anti-tumor immunity.-2 Hyperthermia, the tumor microenvironment and immunity.-3 Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ tumor vaccines.-4 High Intensity Focused Ultrasound (HIFU) Ablation.-5 The interrelationship between cryoablation the immune Response and the tumor microenvironment: Stimulatory and Suppressive Effects.-6 In situ tumor ablation with radiation therapy – its effect on the tumor microenvironment and anti-tumor immunity.-7 Tumor-localized insult delivered by photodynamic therapy and the breakdown of tumor immunotolerance.-8 Effect of electric based ablation treatments on the tumor microenvironment and anti-tumor immunity. Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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