Overview

This volume addresses two important aspects of tuberculosis. The first half reviews some of the biochemistry, genetics and molecular biology of M. tuberculosis and its interactions with macrophages, whilst the second deals with the interactions of the tubercle bacillus with the host immune system in experimental animals and humans, which may lead to the development of protective immunity or may produce immunopathologic reactions and tissue destruction.

Full Product Details

Author:   Thomas M. Shinnick
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Volume:   v.215
Weight:   0.606kg
ISBN:  

9783540609858

ISBN 10:   3540609857
Pages:   318
Publication Date:   05 August 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

List of Contents.- Mycobacterium tuberculosis Cell Envelope.- The Molecular Genetics of Mycobacterium tuberculosis.- Mechanisms of Drug Resistance in Mycobacterium tuberculosis.- Entry of Mycobacterium tuberculosis into Mononuclear Phagocytes.- In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity.- Virulence Determinants of Mycobacterium tuberculosis.- Pathogenesis of Experimental Tuberculosis in Animal Models.- Immune Responses in Animal Models.- Human Cellular Immune Responses to Mycobacterium tuberculosis.- Mechanisms of Anergy in Tuberculosis.- The Koch Phenomenon and the Immunopathology of Tuberculosis.- BCG Vaccination in the Control of Tuberculosis.- Functional T Cell Subsets in Mycobacterial and Listerial Infections: Lessons from Other Intracellular Pathogens.

Reviews

...an excellent treatise dealing comprehensively with all pertinent areas of mycobacteriology, by the leading workers in the field. It is an essential purchase for 'Mycobacteriologists'and is an ideal reference book for all microbiologists wishing to understand the pathogenesis of M. tuberculosis. Brit. Jnl of Biomedical Science'

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