Overview

Tropical diseases remain a major global concern, not only because they affect a huge part of the world population, but also because of the growing global movement of people associated with employment, tourism, and war. Advances in molecular biology, epitomized by the genomic revolution, have brought new promises of powerful scientific approaches to fight such diseases. The WHO's Advisory Committee on Health Research recognizes this fact in its recommendation on Genomics and World Health and stresses the need for concerted efforts by scientists in the developed world, where most of the recent advances in life sciences have occurred, and those in the tropical, mostly less developed countries, where such diseases are endemic. This text exemplifies such an effort. It covers a wide range of topics that reflect perspectives of northern and southern hemispheres. It defines tropical diseases in a broader-than-usual manner. For example, the book discusses traditional tropical medicine topics of infectious diseases and nutritional deficiencies. The book begins with several papers describing the vast human genetic diversity of Southeast Asia and its relationship to several genetic disorders. These papers illustrate the future direction of genomic activities in relation to disease susceptibility and resistance. The next sections deal with malaria and four specific viral and bacterial diseases of the tropics: hepatitis B and C, tuberculosis, and leprosy. These are then followed by a section on general bacterial infection. Two papers on nutrition complete the volume. The book represents the proceedings of the Second International Eijkman Symposium on Tropical Diseases: From Molecule to Bedside: In the Footsteps of Christiaan Eijkman, held September 2-6, 2001, in Bogor, Indonesia.

Full Product Details

Author:   Sangkot Marzuki ,  Jan Verhoef ,  Harm Snippe
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2003 ed.
Volume:   531
Dimensions:   Width: 17.80cm , Height: 3.20cm , Length: 25.40cm
Weight:   1.680kg
ISBN:  

9780306477997

ISBN 10:   0306477998
Pages:   386
Publication Date:   31 July 2003
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Genome and Disease.- Human Genome Diversity and Disease on the Island Southeast Asia.- Mitochondrial Genome and Susceptibility to Diabetes Mellitus.- Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia.- Alpha Thalassemia in Indonesia: Phenotypes and Molecular Defects.- Pathophysiology and Treatment of Iron Overload in Thalassemia Patients in Tropical Countries.- Malaria.- Maria on Islands.- Plasmodium falciparum.- Molecular Basis of Antimalarial Drug Resistance in Indonesia.- Unique properties of respiratory chain in Plasmodium falciparum mitochondria.- Performance of rapid malaria Pf antigen test for the diagnosis of malaria and false-reactivity with autoantibodies.- Phenotypic Switching and var Gene Transcription in Plasmodium falciparum.- Hepatitis B.- Hepatitis B Virus Molecular Diversity in Indonesia.- Transmission Profile of Hepatitis B Virus Infection in the Batam Region, Indonesia.- The Efficacy of a Two-Dose Hepatitis B Vaccination Scheme.- New Options in the Treatment of Chronic Hepatitis.- Hepatitis C.- Prevalence of Hepatitis C Virus Infection among Haemodialysis Patients in West Java, Indonesia.- Molecular Diversity of Hepatitis C Virus in the Batam Region.- New Treatment Options for Chronic Hepatitis C.- Tuberculosis.- pro-Inflammatory Cytokine Response in Acute Infection.- Innate Immunity to Mycobacterium tuberculosis.- Interferon-? production in response to M. Tuberculosis antigens in TB patients in Indonesia.- Immune Reactivation and Paradoxical Worsening in an HIV-Infected Tuberculosis Patient.- Leprosy.- Epidemiology of Leprosy.- Human Deficiencies in Type-1 Cytokine Receptors Reveal the Essential Role of Type-1 Cytokines in Immunity to Intracellular Bacteria.- Elimination of Leprosy and its Consequences forResearch.- General Bacterial Infections.- Antibiotic Resistance: the Pandemic.- Interference of Cryptococcus neoformanswith Human Neutrophil Migration.- Tips and Tricks from Staphylococcus aureus.- A Case of Familial Meningococcal Disease Due to Deficiency in Mannose-Binding Lectin (MBL).- Nutrition.- Micronutrient Deficiency and Supplementation in Indonesian Infants.- Micronutrient Deficiency and Supplementation in Indonesian Infants.

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