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OverviewTransthyretin (TTR) is a thyroid hormone-binding protein, which transports thyroxin from the bloodstream to the brain. The structural stability of TTR in titrimetric form is crucial for maintaining its original functions in blood or cerebrospinal fluid (CSF). The altered structure of TTR due to genetic mutations or its deposits due to aggregation could cause several deadly diseases such as cardiomyopathy and neuropathy in autonomic, motor, and sensory systems. The early diagnoses for hereditary amyloid TTR with cardiomyopathy (ATTR-CM) and wild-type amyloid TTR (ATTRwt) amyloidosis, which result from amyloid TTR (ATTR) deposition, are difficult to distinguish due to the close similarities of symptoms. Thus, many researchers investigated the role of ATTR as a biomarker, especially its potential for differential diagnosis due to its varying pathogenic involvement in hereditary ATTR-CM and ATTRwt amyloidosis. As a result, the detection of ATTR became valuable in the diagnosis and determination of the best course of treatment for ATTR amyloidoses. Assessing the extent of ATTR deposition and genetic analysis could help in determining disease progression, and thus survival rate could be improved following the determination of the appropriate course of treatment for the patient. Here, the perspectives of ATTR in various diseases were presented. Keywords: transthyretin, mutation, protein aggregation, amyloid, amyloidosis Full Product DetailsAuthor: Dr Everistus N SimeonPublisher: Independently Published Imprint: Independently Published Dimensions: Width: 15.20cm , Height: 0.50cm , Length: 22.90cm Weight: 0.127kg ISBN: 9798510971477Pages: 88 Publication Date: 27 May 2021 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: Temporarily unavailable ![]() The supplier advises that this item is temporarily unavailable. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out to you. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |