Overview

Patterns of protein synthesis and gene expression are much influenced by changes in the efficiency of mRNA translation. Translation is controlled at many levels and the complexity of this regulation has been clearly revealed by the recent application of biochemical and genetic techniques. This monograph is a critical and comprehensive account of the numerous control mechanisms observed in eukaryotes. Written and edited by researchers in the field, the book should be of use to specialists and investigators in gene expression, RNA biology and protein synthesis.

Full Product Details

Author:   John W.B. Hershey (University of California, USA) ,  Michael B. Mathews (Cold Spring Harbor Laboratory, New York, USA) ,  Nahum Sonenberg (McGill University, Montreal, Canada)
Publisher:   Cold Spring Harbor Laboratory Press,U.S.
Imprint:   Cold Spring Harbor Laboratory Press,U.S.
ISBN:  

9780879694586

ISBN 10:   0879694580
Pages:   794
Publication Date:   31 December 1996
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Origins and targets of translational control, M.B. Mathews, et al; the pathway and mechanism of eukaryotic protein synthesis, W.C. Merrick, J.W.B. Hershey; a comparative view of initiation site selection mechanisms, R.J. Jackson; binding of initiator methionyl-tRNA to ribosomes, H. Trachsel; protein kinases that phosphoylate eIF2 and eIF2B and their role in eukaryotic cell translational control, M.J. Clemens; translational control mediated by upstream AUG codons, A.P. Geballe; translational control of GCN4 - gene-specific regulation by phosphorylation of eIF2, A.G. Hinnebusch; mRNA 5' cap-binding protein eIF4E and control of cell growth, N. Sonenberg; translational control during heat shock, R.F. Duncan; regulation of protein synthesis by calcium, A.C. Nairn, et al; masked and translatable messenger ribonucleoproteins in higher eukaryotes, A.S. Spirin; translational control of ferritin, T.A. Rouault, et al; translational control of ribosomal protein mRNAs in eukaryotes, O. Meyuhas, et al; ribosomal protein S6 phosphorylation and signal transduction, H.B.J. Jefferies, et al; translational control of developmental decisions, M. Wickens, et al; poly(A) metabolism and translation - the closed-loop model, A. Jacobson; dynamics of poly(A) addition and removal during development, J.D. Richter; interactions between viruses and the cellular machinary for protein synthesis, M.B. Mathews; initiation of translation by picornavirus RNAs, E. Ehrenfeld; adenovirus and vaccinia virus translational control, R.J. Schneider; translational control in cells infected with influenza virus and reovirus, M.G. Katze; translationally coupled degradation of mRNA in eukaryotes, N.G. Theodorakis, et al; regulatory recoding, J.F. Atkins, et al; mammalian ribosomes - the structure and the evolution of the proteins, I.G. Wool, et al; genetics of mitochondrial translation, T.D. Fox; control of translation initiation in prokaryotes, H.O. Voorma.

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