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Author:   Yvan Devaux, PhD (Luxembourg Institute of Health, Luxembourg) ,  Miron Sopić, PhD (Faculty of Pharmacy, University of Belgrade)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
Weight:   0.450kg
ISBN:  

9780443330643

ISBN 10:   0443330646
Pages:   396
Publication Date:   27 October 2025
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Section I – Introduction 1. Atherosclerotic CVD – epidemiology and current challenges in management 2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and Heterogeneity Section II – The role of RNAs in atherosclerosis progression and development 3. Biogenesis and mechanisms of action of ncRNAs 4. The role of ncRNA in plaque development and progression 5. Signaling Pathways Regulating Gene Expression in Atherosclerosis 6. Epitranscriptomics and Atherosclerosis: Section III – Transcriptomic Profiling of Atherosclerotic Lesions 7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond 8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis 9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques 10. Unveiling Sex-Specific Transcriptomic Mechanisms in Atherosclerosis Section IV – Integrating Multi-Omics Approaches in Atherosclerosis Research 11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics 12. Insights into Gene Regulatory Networks in Vascular Pathology 13. Systems Biology and Network Analysis 14. Use of artificial intelligence and machine learning for multi-omics Section V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease 15. RNA Therapeutics in Atherosclerosis: 16. RNA Therapeutic Delivery Systems – advances and challenges 17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and Monitoring Section VI – Conclusion 18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis

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Author Information

Yvan Devaux, Ph.D. explores the frontiers of RNA biology in cardiovascular and neurological disease. With a translational, patient-centered approach, his work bridges disciplines—uniting clinicians, computational biologists, researchers, and industry partners to address urgent medical needs. Devaux’s team has pioneered biomarker discovery pipelines using deep sequencing, AI, and advanced bioinformatics. A seasoned leader of large-scale research consortia, he now focuses on the heart-brain axis, uncovering RNA biomarkers that illuminate the complex interplay between brain and heart disease. This volume captures his vision for collaborative, data-driven innovation in precision medicine. Miron Sopić, Ph.D. is an Associate Professor of Medical Biochemistry at the Faculty of Pharmacy, University of Belgrade. He teaches biochemistry with a strong emphasis on its diagnostic applications, grounded in his scientific expertise. His research centers on inflammation in cardiometabolic diseases, particularly the discovery of RNA-based biomarkers. Dr. Sopić is the author of more than 54 scientific publications and was awarded the Marie Skłodowska-Curie Postdoctoral Fellowship in 2022. This fellowship enabled his collaboration with Dr. Yvan Devaux at the Luxembourg Institute of Health, where they are exploring epitranscriptomic signatures in atherosclerosis—pushing the boundaries of cardiovascular molecular medicine.

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