Overview

Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.

Full Product Details

Author:   Martin L. Privalsky
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2001
Volume:   254
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.454kg
ISBN:  

9783642087097

ISBN 10:   3642087094
Pages:   190
Publication Date:   15 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

List of Contents.- Molecular Mechanisms of Corepressor Function.- Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism.- Corepressor Proteins and Control of Transcription in Yeast.- Corepressor Proteins in Drosophila Development.- Corepressors and Nuclear Hormone Receptor Function.- Regulation of SMRT and N-CoR Corepressor Function.- Corepressors and Retinoblastoma Protein Function.- Smad Transcriptional Corepressors in TGF? Family Signaling.- Role of Nuclear Receptor Corepressors in Leukemogenesis.

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