Overview

The E2F gene family of transcription factors is a regulator of the G1 to S phase transition of mammalian cell cycle. This volume details which cellular genes are thought to be regulated by E2F and describes models for E2F action based on protein-protein complexes that either positively or negatively influence cell growth. Also documented are the effects of altered E2F activity, achieved either by viral transformation or overexpression of E2F family members. Finally, a comparison is provided between E2F and cell cycle regulators from yeast, in the hopes that parallels can be drawn that will provide insight into G1/S phase specific transcription in mammalian cells.

Full Product Details

Author:   Peggy J. Farnham
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v.208
Weight:   0.370kg
ISBN:  

9783540601135

ISBN 10:   3540601139
Pages:   151
Publication Date:   12 December 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

List of Contents.- to the E2F Family: Protein Structure and Gene Regulation.- Regulatory Interactions Among E2Fs and Cell Cycle Control Proteins.- Use of the E2F Transcription Factor by DNA Tumor Virus Regulatory Proteins.- The Cellular Effects of E2F Overexpression.- Start-Specific Transcription in Yeast.- Conclusions and Future Directions.

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