Overview

The present volume, authored by leading experts in the field, contains in-depth information regarding the role of transcription factors as key players in the execution of the genomic program of any given cell. Many of the chapters focus on the role of transcription factors in cellular transformation and cancer, other chapters highlight the contributions of transcription factors to inflammatory responses or xenobiotic responses. Moreover, the volume illustrates how a viral transcription factor interferes with the physiology of its host cell and finally points out how much exciting research transcription factor biology still has to offer.

Full Product Details

Author:   Manfred Gossen ,  Jörg Kaufmann ,  Steven J. Triezenberg
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2004 ed.
Volume:   166
Dimensions:   Width: 15.50cm , Height: 3.30cm , Length: 23.50cm
Weight:   1.160kg
ISBN:  

9783540210955

ISBN 10:   3540210954
Pages:   581
Publication Date:   27 August 2004
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1. An Introduction to Transcription Factors.- Mechanisms of Transcriptional Activation in Eukaryotes.- Multiple Mechanisms of Transcriptional Repression in Eukaryotes.- Genomic Approaches to the Study of Transcription Factors.- 2. Transcription Factors in Pathophysiology.- Biological Roles of the STAT Family in Cytokine Signaling.- Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis.- Transcription Factors in the Control of Tumor Development and Progression by TGF-? Signaling.- The p53 Transcription Factor as Ther apeutic Target in Cancer.- The Role of Ets Transcription Factors in Mediating Cellular Transformation.- Function of the E2F Transcription Factor Family During Normal and Pathological Growth.- c-Myc in Cellular Transformation and Cancer.- NF-?B: Critical Regulator of Inflammation and the Immune Response.- Hepatitis BVirus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis.- Regulation of Xenobiot ic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology.- 3. Exogenous Control of Transcription Factor Activity.- Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approach.- Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatment.- Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine.- Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications.- Modulating Transcript ion with Artificial Regulators.

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