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OverviewToxoplasma gondii is an important parasite causing economic losses in agriculture, congenital abnormalities in man and fatal disease in immunosuppressed individuals. Recently there has been a resurgence of interest in the parasite. This is partially due to the increased clinical importance of toxoplasmosis: the disease kills 25 % of AIDS patients. However, hit is also because the parasite provides a tractable model system for molecular, cellular and immunological investigation of intracellular parasites. The book is divided into four sections: three basic science sections on molecular biology, cell biology, and immunology of toxoplasmosis, with a final section reviewing applied issues such as vaccination, chemotherapy, and diagnosis. Full Product DetailsAuthor: Judith E. SmithPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Volume: v. 78 Weight: 0.530kg ISBN: 9783540573050ISBN 10: 3540573054 Pages: 273 Publication Date: 20 December 1993 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsMolecular Biology.- Allelic polymorphyism in Toxoplasma gondii: implications for interstrain mating.- Study of genetic polymorphism of Toxoplasma gondii through isoenzyme analysis.- Expression of apical organelle antigens by a Toxoplasma gondii genomic library.- Dense granule antigens of Toxoplasma gondii.- A strategy for cloning a DNA polymerase gene of Toxoplasma gondii.- Extrachromosomal DNA in the Apicomplexa.- Cell Biology.- Formation and modification of the parasitophorous vacuole occupied by Toxoplasma gondii.- The parasitophorous vacuole membrane surrounding T. gondii: a specialized interface between parasite and cell.- Toxoplasma gondii: Motility and Invasion.- Toxoplasma gondii: Patterns of bradyzoite-tachyzoite interconversion in vitro.- The growth and development of Toxoplasma gondii tissue cysts in vitro.- Recent advances in the glycobiology of Toxoplasma gondii.- Immunology.- Role of P30 in attachment and immunity to T gondii.- Secretory IgA, antibody to SAG1, H-2 class I-restricted CD8+ T-lymphocytes and the INT1 locus in protection against Toxoplasma gondii.- Factors responsible for development of toxoplasmic enchephalitis in immunocompromised hosts.- Synergistic and compensatory roles of CD4+, CD8 + T-lymphocytes and natural killer cells in resistance to Toxoplasma gondii.- Human T-cell clones as tools to identify protective antigens of Toxoplasma gondii.- Protection of mice and nude rats against Toxoplasmosis by an octomaeric construct of the P30 48-67 peptide.- Toxoplasmosis Vaccines Diagnosis & Chemotherapy.- Synergistic drug combinations in the treatment of toxoplasmosis.- Toxoplasma gondii: Chemotherapy.- Diagnosis of Toxoplasma gondii infections by molecular detection.- Use of Toxoplasma gondii recombinant antigens for diagnosis and seroepidemiology.- Progress towards the development of a vaccine against congenital toxoplasmosis: Identification of protective antigens and the selection of appropriate adjuvants.- Development of a live vaccine against ovine toxoplasmosis.- Abstracts.- Genetic regulation of Toxoplasma gondii infection: influence of LSH/ITY/BCG gene.- Establishing a laboratory for parasitic genome analysis: focus on the parasitic protozoa Toxoplasma, Trypanosoma and Leishmania.- Mucosal immune response in Tpxoplasmosis.- Antenatal screening for Toxoplasmosis in Turkiye.- Toxoplasmosis in Greece: Serological studies.- Critical evaluation of IgA antibodies as an indication of early Toxoplasma-infection.- Expression of Toxoplasma gondii genes in rBCG.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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