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OverviewFull Product DetailsAuthor: Shayne Cox Gad (Gad Consulting Services, Raleigh, North Carolina, USA)Publisher: Taylor & Francis Ltd Imprint: CRC Press Edition: 2nd edition Weight: 0.793kg ISBN: 9781138360167ISBN 10: 1138360163 Pages: 464 Publication Date: 30 October 2018 Audience: Adult education , Professional and scholarly , Further / Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsPreface Editor Contributors Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ Shayne C. Gad Chapter 2 Methods for the Analysis of Gastrointestinal Function Robin C. Guy Chapter 3 Safety Pharmacology and the GI Tract Henry I. Jacoby Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration Robert W. Kapp, Jr. Chapter 6 Gastrointestinal Function and Toxicology in Canines Charles B. Spainhour Chapter 7 Gastrointestinal Function and Toxicology in Minipigs Maria R. Jones and Alain Stricker-Krongrad Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium Shayne C. Gad Chapter 9 Peyer’s Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome Gary R. Burleson and Florence G. Burleson Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models Shayne C. Gad Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract Shayne C. Gad Chapter 12 Normal and Abnormal Intestinal Absorption by Humans David W. Hobson and Valerie L. Hobson Balldin Chapter 13 Classes of Compounds with GI Tract Toxicity Amy L. Mihalchik and Erica N. Rogers Chapter 14 Species Differences in GI Toxicity Shayne C. Gad Chapter 15 Nanoparticles in the Gastrointestinal Tract David W. Hobson and Valerie L. Hobson Balldin IndexReviewsAuthor InformationShayne C. Gad, B.S. (Whittier College, Chemistry and Biology, 1971) and Ph.D. in Pharmacology/Toxicology (Texas, 1977), DABT, is the principal of Gad Consulting Services, a twenty-seven-year-old consulting firm with nine employees and more than 500 clients (including 140 pharmaceutical companies in the US and 50 overseas in 29 countries). Prior to this, he served in director-level and above positions at Searle, Synergen and Beckton Dickinson. He has published 50 books and more than 350 chapters, articles, and abstracts in the fields of toxicology, statistics, pharmacology, drug development and safety assessment. He has more than 42 years of broad-based experience in regulatory toxicology, drug and device development, statistics and risk assessment, and has specific expertise in neurotoxicology, in vitro methods, cardiovascular toxicology, inhalation toxicology, immunotoxicology, risk assessment, and genotoxicology. He is a past president of the American College of Toxicology, the Roundtable of Toxicology Consultants and three of SOT’s specialty sections. He has direct involvement in the preparation of INDs (118 successfully to date), NDA, PLA, ANDA, 501(k), IDE, CTD, clinical data bases for phase 1 and 2 studies, and PMAs, and served as the COO of two pharmaceutical companies while a consultant. He has consulted for FDA, EPA, and NIH, has trained reviewers and been an expert witness for FDA. He has also conducted the triennial toxicology salary survey as a service to the profession for the last 29 years. Dr. Gad is also a retired Navy officer with more than 26 years in service. Tab Content 6Author Website:Countries AvailableAll regions |
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