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Author:   Tohru Inoue ,  William T. Pennie ,  W.D. Penni
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   2003 ed.
Dimensions:   Width: 15.50cm , Height: 1.60cm , Length: 23.50cm
Weight:   0.649kg
ISBN:  

9784431703440

ISBN 10:   4431703446
Pages:   228
Publication Date:   09 October 2002
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Introductory Keynotes.- Introduction: Toxicogenomics — A New Paradigm of Toxicology.- Toxicogenomics in Genome Science World.- Application of Transcript Profiling to Mechanism-Based Toxicology.- Strategy for Toxicogenomics.- Application of DNA Microarrays for Predicting Toxicity and Evaluating Cross-Species Extrapolation.- Use of Reverse Genetics and cDNA Arrays to Understand ‘Dioxin’ Toxicity.- Technical Development (Genomics and Proteomics).- Applications of Gene Arrays in Toxicology.- The ToxExpress™ Module: Applying Gene Expression Data to Predictive Toxicology.- Taming the Mass of Microarray Data: Systematic Approaches to Gene Expression Analysis.- Applications of ProteinChip® Systems in Toxicological Assessment.- Experimental Applications (1) — Oncology Research.- Toxicogenomics: Making Progress by Maintaining a Focus on the Fundamentals of Toxicology.- A Microarray Analysis of Differential Gene Expression Associated with the Development of Doxorubicin Resistance in Breast Carcinoma.- Screening Trial of Cancer Chemopreventive Agent by Using Combination of DNA Chip Technology and Cell Signaling Network DataBase (CSNDB).- Application of Methacarn Fixation for Genetic Analysis in Microdissected Paraffin-Embedded Tissue Specimens.- Experimental Applications (2) — Xenobiotic Metabolism.- ABC Transporters: A New Approach to Toxicogenomics.- SXR and the Xenobiotic Response.- Experimental Applications (3) — Endocrine Disruptor Research.- C. elegance as a Tool for Environmental Toxicology.- Development of the Test Method for Detection of Endocrine-Disrupting Activity Using DNA Microarrays.- Application of cDNA Microarray for Uterotrophic Assay.- Large-Scale Gene Expression Analysis for Evaluation of Endocrine Disruptors.- Analysis of Toxicogenomic Responseto Endocrine Disruptors in the Mouse Testis.- Gene Expression Profiling to Identify Mechanisms of Male Reproductive Toxicity.- Future Prospects and Risk Assessment.- Toxicology and Genetic Toxicology in the New Era of “Toxicogenomics”: Impact of “-omics” Technologies.- Use of Genomics in Mechanism Based Risk Assessment.- Chemogenomics for Predictive Drug Assessment.- Reverse Toxicology as a Future Predictive Toxicology.

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