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OverviewThis authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation. Full Product DetailsAuthor: Vinod P. Shah , Howard I. MaibachPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of the original 1st ed. 1993 ISBN: 9781489912640ISBN 10: 1489912649 Pages: 453 Publication Date: 14 December 1994 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsTopical Drug Delivery: Percutaneous Absorption (R.C. Wester, H.I. Maibah). Transdermal Delivery Systems (G.W. Cleary). In vitro Methodology: Practical Considerations in Developing a Quality Control (In vitro release) Procedure for Dermatological Products (V.P. Shah, J.P. Skelly). Diffusion Cell Design (R.L. Bronaugh). In vivo Methodology: In vivo Topical Bioavailability and Skin Decontamination (R.C. Wester, H.I. Maibach). Grafted Skin and Skin Flaps (J.E. Riviere). Factors Influencing Percutaneous Transport: In vivo and In vitro Skin Uptake and Permeation Studies (C.R. Behl et al.). The Dose Response of Percutaneous Absorbtion (R.C. Wester, H.I. Maibach). Modelling and Correlations: Pharmacokinetic and Pharmacodynamic Modelling of Transdermal Products (S.K. Gupta et al.). Animal Models for Percutaeous Absorption (R.C. Wester, H.I. Maibach). 14 additional articles. Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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