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Overview"A concise assessment of the risks to human health posed by exposure to ""ortho""-toluidine, a chemical used in the manufacture of dyestuffs and, to a lesser extent, in the production of rubber, chemicals and pesticides, and as a curing agent for epoxy resin systems. The document is part of a new series of brief reports aimed at the characterization of hazards and dose-response for exposures to selected industrial chemicals. With this goal in mind, documents in the series focus on studies and findings considered critical for risk characterization. The document is primarily concerned with assessing the carcinogenic risk in occupationally exposed workers. A review of findings from studies in rats and mice, where oral administration of ""o""-toluidine has been linked to a significant increase in the incidence of benign and malignant tumors, supports the conclusion that ""o""-toluidine may act as a genotoxic carcinogen. In humans, limited epidemiological evidence suggests an increased risk of bladder cancer in occupationally exposed workers. In view of evidence that the chemical's carcinogenic action involves a genotoxic mechanism, the assessment was unable to identify a threshold at which exposure would not result in some risk to human health." Full Product DetailsAuthor: World Health Organization , World Health Organization , UNAIDS , World Health OrganizationPublisher: World Health Organization Imprint: World Health Organization Volume: No. 7 Dimensions: Width: 21.00cm , Height: 0.30cm , Length: 29.00cm Weight: 0.010kg ISBN: 9789241530071ISBN 10: 9241530073 Pages: 18 Publication Date: 01 March 1998 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of stock The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |