Overview

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

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9780128016633

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Dr. Takehiko Nohmi is currently a Visiting Scientist and Scientist Emeritus at Biological Safety Research Center, National Institute of Health Sciences Kamiyoga, Tokyo, Japan; and Science Coordinator at Japan Agency for Medical Research and Development Tokyo, Japan. Shoji Fukushima is currently the Director of the Japan Bioassay Research Center, Japan Industrial Safety & Health Association, Kanagawa Japan.

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