Therapeutic Antibodies: Methods and Protocols

Author:   Gunnar Houen
Publisher:   Springer-Verlag New York Inc.
Edition:   1st ed. 2022
Volume:   2313
ISBN:  

9781071614495


Pages:   347
Publication Date:   04 September 2021
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Therapeutic Antibodies: Methods and Protocols


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Author:   Gunnar Houen
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2022
Volume:   2313
Weight:   0.881kg
ISBN:  

9781071614495


ISBN 10:   1071614495
Pages:   347
Publication Date:   04 September 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Therapeutic Antibodies: An Overview Gunnar Houen 2. Treatment of Autoimmune Diseases with Therapeutic Antibodies: Lessons Learned from PID Patients Allow for Stratification of the Infection Risk Joyce J.B.C. van Beers and Jan G.M.C. Damoiseaux 3. B-Cell Analysis for Monitoring Patients Undergoing B-Cell Depletion for the Treatment of Autoimmune Diseases Jan G.M.C. Damoiseaux, Joyce van Beers, Matthias Busch, and Pieter van Paassen 4. Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods Adriana-Michelle Wolf Perez, Nikolai Lorenzen, Michele Vendruscolo, and Pietro Sormanni 5. The Therapeutic Antibody Profiler for Computational Developability Assessment Matthew I.J. Raybould and Charlotte M. Deane 6. Short Read-Length Next-Generation DNA Sequencing of Antibody CDR Combinations from Phage Selection Outputs Landon Pastushok, Kris Barreto, and C. Ronald Geyer 7. Large Scale Transient Production in ExpiCHO-STM with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection Xiaotian Zhong, Ashley Schwab, Weijun Ma, Caryl L. Meade, Jing Zhou, Aaron M. D' Antona, Will Somers, and Laura Lin 8. Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris Laia Montoliu-Gaya and Sandra Villegas 9. Purification of Therapeutic Antibodies by Protein A Affinity Chromatography Anurag S. Rathore and Sharad Narnaware 10. Ion Exchange Chromatographic Methods for Purification of Therapeutic Antibodies Anurag S. Rathore and Vishwanath Hebbi 11. Structure-Indicated LC-MS/MS Bioanalysis of Therapeutic Antibodies Noriko Iwamoto and Takashi Shimada 12. Use of PASEF for Accelerated Protein Sequence Confirmation and De Novo Sequencing with High Data Quality Detlev Suckau, Waltraud Evers, Eckhard Belau, Stuart Pengelley, Anja Resemann, Wilfred Tang, K. Ilker Sen, Elsa Wagner, Olivier Colas, and Alain Beck 13. Nano-Microscopy of Therapeutic Antibody Aggregates in Solution Yukako Senga, Toshihiko Ogura, Hiroshi Imamura, and Shinya Honda 14. Measuring Self-Association of Antibody Lead Candidates with Dynamic Light Scattering Fabian Dingfelder, Anette Henriksen, Per-Olof Wahlund, Paolo Arosio, and Nikolai Lorenzen 15. Intact Mass Quantitation of Therapeutic Antibodies for Pharmacokinetic Studies Using Immuno-Purification Lisa A. Vasicek, Daniel S. Spellman, and Kevin P. Bateman 16. Detection of Residual Host Cell Proteins in Biotherapeutic Drugs by Concatenated 2D LC-MS/MS Feng Yang, Delia Li, and Donald E. Walker 17. Bioassays for the Evaluation of Target Neutralization and Complement-Dependent Cytotoxicity (CDC) of Therapeutic Antibodies Nohemi Salinas-Jazmin, Emilio Medina-Rivero, and Marco Antonio Velasco-Velazquez 18. Methods for Functional Characterization of FcRn Interactions with Therapeutic Antibodies and Fc-Fusion Proteins Shan Chung, Yuwen L. Lin, Van Nguyen, and Chang Liu 19. Method for Measurement of Antibody-Dependent Cellular Phagocytosis Lynn Kamen, Benjamin Ordonia, Srividya Myneni, and Shan Chung 20. Bioluminescent Bridging Immunoassay for Anti-Drug Antibody (ADA) Detection Nidhi Nath, Becky Godat, Rod Flemming, and Marjeta Urh 21. A Surface Plasmon Resonance-Based Assay for Simultaneous Measurement of Serum Concentrations of Therapeutic Antibodies and Anti-Drug Antibodies Marten Beeg, Eleonora Allocati, and Marco Gobbi

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