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OverviewUbiquitin-proteosome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This text tells the story of the ubiquitin system as we know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteosome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes. Full Product DetailsAuthor: Aaron J Ciechanover (Technion-israel Inst Of Tech, Israel) , Maria Grazia Masucci (Karolinska Inst, Sweden)Publisher: World Scientific Publishing Co Pte Ltd Imprint: World Scientific Publishing Co Pte Ltd Volume: 9 ISBN: 9789812381002ISBN 10: 9812381007 Pages: 240 Publication Date: 19 November 2002 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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