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OverviewFull Product DetailsAuthor: R. John Mayer , Aaron J. Ciechanover , Martin RechsteinerPublisher: Wiley-VCH Verlag GmbH Imprint: Wiley-VCH Verlag GmbH Edition: Volume 2 Volume: v. 2 Dimensions: Width: 18.40cm , Height: 2.00cm , Length: 24.30cm Weight: 0.690kg ISBN: 9783527311309ISBN 10: 3527311300 Pages: 300 Publication Date: 10 February 2006 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of ContentsDegrons: signals and sites for ubiquitylation The proteasome portal and regulation of proteolysis PAN and the proteasome Ubiquitin domain proteins MEKK1: dual function as a protein kinase and a ubiquitin protein ligase HECT domain ubiquitin protein ligases UCRP: ubiquitin cross-reactive protein SUMOs and their function in the cell Functions of the ubiquitin-proteasome pathway Molecular Chaperones and the ubiquitin/proteasome system Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes Electron microscopy of compartmentalised proteases Molecular dissection of autophagy in yeastReviews... a comprehensive chapter on the structure of large, self-compartmentalizing proteases ... gives an overview how complex these 'molecular machines' are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately. (Zellbiologie aktuell) The series - when completed - is likely to become a comprehensive work of reference on the ubiquitin/proteasome system. (ChemBioChem) ... a comprehensive chapter on the structure of large, self-compartmentalizing proteases ... gives an overview how complex these 'molecular machines' are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately. (Zellbiologie aktuell) The series - when completed - is likely to become a comprehensive work of reference on the ubiquitin/proteasome system. (ChemBioChem) ... a comprehensive chapter on the structure of large, self-compartmentalizing proteases ... gives an overview how complex these 'molecular machines' are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately. Zellbiologie aktuell The series - when completed - is likely to become a comprehensive work of reference on the ubiquitin/proteasome system. ChemBioChem Author InformationJohn Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University. For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses. Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system. Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation. Tab Content 6Author Website:Countries AvailableAll regions |
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