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OverviewIn comparison with antibacterial chemotherapy the clinical use of specific antiviral drugs is a fairly recent development. By the 1950s a number had been discovered, but their clinical application was delayed until 1962, when methisazone was used for the treatment of infective complications of smallpox vaccination and idoxuridine in the treatment of herpetic keratitis. In retrospect the reasons for this slowness in development is now evident. It was due in large part to the prevailing view held at the time that virus infections could never be treated with specific agents, since the multiplica tion of virus is so closely integrated with the metabolic processes of the host cell that specificity of action seemed impossible of achievement. In contrast, bacteria were independent entities with metabolic systems differing widely from those of the mammalian host, which afforded points of attack by specific agents which had no action upon mammalian systems. Although the mode of action of the sulphonamides and penicillin was not known for some time, they afforded perfect examples of the success of this mode of attack. Full Product DetailsAuthor: D.J. BauerPublisher: Springer Imprint: Springer Edition: Softcover reprint of the original 1st ed. 1977 Dimensions: Width: 15.50cm , Height: 1.10cm , Length: 23.50cm Weight: 0.326kg ISBN: 9789401179232ISBN 10: 9401179239 Pages: 194 Publication Date: 27 May 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1 An introduction to the viruses.- 2 Viruses in relation to chemotherapy.- 3 Antiviral agents-I The antiviral nucleosides.- Cytarabine.- Idoxuridine.- Trifluorothymidine.- Vidarabine.- 4 Antiviral agents-II Amantadine hydrochloride and methisazone.- 5 Chemotherapy of herpesvirus infections-I Herpes and B virus.- 6 Chemotherapy of herpesvirus infections-II Varicella-zoster and cytomegalovirus.- 7 Chemotherapy of poxvirus infections.- 8 Chemotherapy of myxovirus and papovavirus infections.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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