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This dissertation, The Role of Computed Tomography Volumetry in the Assessment of Advanced Lung Cancer and Oesophageal Cancer by Tsz-chung, Yip, 葉子仲, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled The Role of Computed Tomography Volumetry in the assessment of Advanced Lung Cancer and Oesophageal Cancer submitted by Yip Tsz Chung (1995477511) for the Degree of Master of Philosophy (MPhil) at The University of Hong Kong in March 2001 The aims of this study were to evaluate the significance of baseline computed tomography (CT) tumour volume (TV), lymph node volume (NV) and largest tumour area (LTA) on symptoms, metastases and survival in advanced (stages III and IV only) non small cell lung carcinoma (NSCLC), and the significance of baseline and post-treatment CT TV on tumour- (T), nodal- (N) stage, overall stage and survival in oesophageal (OC). Data from 47 cases (31 males; 16 females; median age 59) of advanced (stages III & IV) NSCLC and 45 cases (39 males; 6 females; median age 64) of OC were analysed. Volumes were measured by CT volumetry. For advanced NSCLC, positive correlations were found between TV and NV (r=0.488, plong-term (24 months) survival although NV > 11 cm was associated with a poorer short-term (12 months) survival (p=0.034). For OC, baseline TV was highly correlated with post-treatment TV (r=0.858, pIn summary, although TV and NV in NSCLC were not independent long- term prognostic indicators, they were related to expression of haemoptysis and sputum. NV in NSCLC also had important relationships with regional spread to cervical lymph nodes and pleura. Gender and age may influence NV and metastatic spread to cervical nodes. Largely similar results obtained with LTA, reflecting that of TV, imply that LTA could be used as a measure of tumour size in NSCLC. With respect to OC, this study has therefore highlighted the significance of monitori

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