Overview

"PCBs have captured the attention of scientists, journalists and the public since the 1960s, but during most of that time attention was focused on a small number of the 209 possible chlorobiphenyls. Work in the 1990s has implicated many of the forgotten and/or unstudied congeners as neuro-endocrine active and potential developmental toxicants. This interest has created a need for information regarding the ""non-dioxin-like"" PCBs. This study integrates historical information, analytical interpretations, and global concepts with comprehensive residue reports and public health concerns. The data should improve the accuracy of concepts regarding the occurrence and disposition of the 60-100 (rather than 6-10) most important congeners. Actual PCB burdens are shown to deviate from average steady-state profiles through sporadic exposures to unique mixtures characteristic of individual dietary sources."

Full Product Details

Author:   Larry G. Hansen
Publisher:   Springer
Imprint:   Springer
Edition:   1999 ed.
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   1.270kg
ISBN:  

9780792385417

ISBN 10:   0792385411
Pages:   269
Publication Date:   31 July 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1. PCBs: Production and Properties.- 2. The Individual Chlorobiphenyls.- 2.1 GC Retention Times.- 2.2 Other Properties.- 2.3 Congener. Abundance in Former Commercial Mixtures.- 2.4 Congener-Specific Biological Properties.- 3. Interpretation of Analytical Data.- 3.1. Low Resolution GC and Pattern Recognition.- 3.2. Transition from Low Resolution to High Resolution GC.- 3.3. Selection of Analytes.- 4. Atmospheric Transport.- 4.1. Global Compartments.- 4.2 Atmospheric PCB Levels.- 4.3. Dispersion of airborne PCBs.- 4.4. Global Fractionation.- 4.5. Character of Localized Emissions.- 4.6. Accumulation of Airborne PCBs by Vegetation.- 4.7. Other Environmental Pathways for Airborne PCBs.- 4.8 Summary.- 5. The Hydrosphere and Lithosphere.- 5.1. Relative Magnitude of Reservoirs.- 5.2. Movement and Fluxes of PCBs Among Reservoirs.- 5.3. Bioconcentration of PCBs from Water.- 5.4. Bioaccumulation from Multiple Pathway Exposures.- 6. Metabolism and Metabolites.- 6.1 Gone But Not Forgotten.- 6.2 Mass Balance.- 6.3 Oxidative Metabolism.- 6.4 Phase 2 and Phase 3 Metabolism.- 6.5. Dose, Time, Induction and Biotransformation Rates.- 7. Disposition and Toxicokinetics.- 7.1. Toxicokinetics.- 7.2 Very basic toxicokinetic models.- 7.3. Models of oral exposure.- 7.4. PBPK Model of early disposition.- 7.5 Toxicokinetics in Other Classes of Animals.- 7.6. Toxicokinetics and PCB Residue Profiles.- 8. Food Chain Profiles.- 8.1. PCB profiles in fish.- 8.2. PCB profiles in marine mammals.- 8.3. Other profile-altering PCB exposures.- 8.4. Reporting of Human PCB Residues.- 8.5. Characterizing Human PCB Residues.- 8.6. Model of infant exposure to PCBs in human breast milk.- 8.7. Final considerations.- References.- Appendices.- 1. Nomenclature of Polychlorinated Biphenyls.- 2. PCB Congener Weight % inAroclors of 5 Types.- 3. Some Properties of Chlorobiphenyls.- 4. Estimation of PCB Congener Production Ratios.- 5. Comparison of Human Residues Reported by Sample Authors Without Standards Available.- 6. Airborne PCBs.- 7. Percent Congener Composition of PCBs in Various Plants.- 8. Dispersion in Air.- 9. Sediments and Water.- 10. PCB Residues in Fish from the Great Lakes.- 11. “Average” Fish Residue Profiles.- 12. Average Human Milk.- 13. Frequencies of Congener Occurrence in Breast Milk Surveys.- 14. Abbreviations.

Reviews

`... this source book is useful for both novices and experts in PCB research and interpretation. It is a most valuable addition to the existing, dispersed literature in the professional journals. It will help both the student researching PCB's in the food chain and the policy-maker, looking for insight into the principles underlying the monitoring and control of this problem, which will continue to rank high on the environmental agenda for years to come.' Luc Hens, Human Ecology Department, Free University Brussels

... this source book is useful for both novices and experts in PCB research and interpretation. It is a most valuable addition to the existing, dispersed literature in the professional journals. It will help both the student researching PCB's in the food chain and the policy-maker, looking for insight into the principles underlying the monitoring and control of this problem, which will continue to rank high on the environmental agenda for years to come.' Luc Hens, Human Ecology Department, Free University Brussels

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