Overview

Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.

Full Product Details

Author:   Stuart A. Kauffman (Professor of Biochemistry, Professor of Biochemistry, University of Pennsylvania)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Dimensions:   Width: 15.50cm , Height: 3.40cm , Length: 23.30cm
Weight:   1.002kg
ISBN:  

9780195079517

ISBN 10:   0195079515
Pages:   734
Publication Date:   16 September 1993
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

1: Conceptual Outline of Current Evolutionary Theory PART I: Adaptation on the Edge of Chaos 2: The Structure of Rugged Fitness Landscapes 3: Biological Implications of Rugged Fitness Landscapes 4: The Structure of Adaptive Landscapes Underlying Protein Evolution 5: Self Organization and Adaptation in Complex Systems 6: Coevolving Complex Systems PART II: The Crystallization of Life 7: The Origins of Life: A New View 8: The Origin of a Connected Metabolism 9: Autocatalytic Polynucleotide Systems: Hypercycles, Spin Glasses and Coding 10: Random Grammars PART III: Order and Ontogeny 11: The Architecture of Genetic Regulatory Circuits and Its Evolution 12: Differentiation: The Dynamical Behaviors of Genetic Regulatory Networks 13: Selection for Gene Expression in Cell Type 14: Morphology, Maps and the Spatial Ordering of Integrated Tissues

Reviews

... an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. Stephen Jay Gould Stuart Kauffman's book ... is a global representation of a new field, that will greatly enhance our physical understanding of Nature ... A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. Manfred Eigen Here is a big book with a big purpose... The Origins of Order is the first book to be written by any of the complexity theorists themselves, and it presents Kauffman's view of the biological realm... The Origins of Order will be seen as a major work in the progression of biological theory. At the very least, Kauffman has made a persuasive case to have his bold hypothesis heard. Roger Lewin

... an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. Stephen Jay Gould Stuart Kauffman's book ... is a global representation of a new field, that will greatly enhance our physical understanding of Nature ... A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. Manfred Eigen Here is a big book with a big purpose... The Origins of Order is the first book to be written by any of the complexity theorists themselves, and it presents Kauffman's view of the biological realm... The Origins of Order will be seen as a major work in the progression of biological theory. At the very least, Kauffman has made a persuasive case to have his bold hypothesis heard. Roger Lewin

Biology is the science of the organizational principles that make living things living. Kauffman's book is a massive attempt to provide the foundations for a theory of such organization. . .The book is as much an explication of a specific style of scientific thinking as it is a book on adaptation, the origin of life, and ontogeny. The style of thinking can be characterized by the assumption that there are deep and simple conceptual structures that will allow us to understand life and not merely describe it. . .I hope that Kauffman's book will be a strong stimulus for many scientists to search actively for the principles that govern the organization of living states of matter. --Science This book does a real service in building a bridge between reductionist and holistic ways of thinking about systems. . .Kauffman writes with great intelligence and clarity and is able to bring together a large range of theory and experimental information without getting bogged down in detail. --Whole Earth Review For all the recent advances in molecular biology, we still lack a convincing explanation of how self-organising and self-replicating entities originated. Stuart Kauffman enters this arena with a book that seeks to show that self-organising structures of great complexity can assemble themselves much more easily, and much more understandably, than previous intuition suggested. . .Building on recent work in nonlinear mathematics, the idea at the heart of the book is truly important: even in vastly complicated interactive networks, a few simple rules can easily--if amazingly--lead to order and self-organised patterns and processes. This represents a major advance in understanding how the living world works. --Robert M. May, The Observer Stuart Kauffman's book. . .is a global representation of a new field, that will greatly enhance our physical understanding of Nature. It treats from a physical standpoint the processes of molecular selfordering, as biologists witness them in the living world, and it does so in a most original and authoritative way. A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. --Manfred Eigen, Max-Planck Institut fur Biophysikalische Chemie There are very few people in this world who ever ask the right questions of science, and they are the ones who affect its future most profoundly. Stuart Kauffman is one of these. Read this book. --Philip Anderson, Nobel Laureate, Dept. of Physics, Princeton University The conventional concept of Darwinian evolution views populations of organisms as randomly varying systems shaped to adaptation by the external force of natural selection. But Darwinian theory must be expanded to recognize other sources of order based on the internal genetic and developmental constraints of organisms and on the structural limits and possibilities of general physical laws. Stu Kauffman has been exploring these unorthodox sources of order for many years and has now produced an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. --Stephen Jay Gould, Harvard University Has there been time, since the origin of life on earth, for natural selection to produce the astonishing complexity of living organisms? Kauffman offers a new and unorthodox answer to this question. Given what we know about the way genes signal to one another, he argues that complexity can arise more readily than one would expect. I am not sure he is right, but I am sure that we should take his ideas seriously. --John Maynard Smith, University of Sussex Professor Kauffman's book is highly imaginative and provocative. --Lewis Wolpert, University College and Middlesex School of Medicine The facile claim that natural selection can accomplish every adaptive change fails to grapple with the problems posed by a highly structured system with its own laws of assembly and interaction. Stuart Kauffman's book, The Origins of Order, returns the problem of evolution to the central issue that evolutionists have been avoiding for too long, the problem of the evolution of a complex, organized system that we call, appropriately, an organism. Evolutionists had better take Kauffman's arguments seriously. --Richard C. Lewontin, Harvard University I rarely agree with Stuart Kauffman, but I always enjoy arguing with him. If you are interested in novel theories, buy this book--you will find lots of ideas worth wrestling with. --Leslie E. Orgel, The Salk Institute Biology is the science of the organizational principles that make living things living. Kauffman's book is a massive attempt to provide the foundations for a theory of such organization. . .The book is as much an explication of a specific style of scientific thinking as it is a book on adaptation, the origin of life, and ontogeny. The style of thinking can be characterized by the assumption that there are deep and simple conceptual structures that will allow us to understand life and not merely describe it. . .I hope that Kauffman's book will be a strong stimulus for many scientists to search actively for the principles that govern the organization of living states of matter. --Science This book does a real service in building a bridge between reductionist and holistic ways of thinking about systems. . .Kauffman writes with great intelligence and clarity and is able to bring together a large range of theory and experimental information without getting bogged down in detail. --Whole Earth Review For all the recent advances in molecular biology, we still lack a convincing explanation of how self-organising and self-replicating entities originated. Stuart Kauffman enters this arena with a book that seeks to show that self-organising structures of great complexity can assemble themselves much more easily, and much more understandably, than previous intuition suggested. . .Building on recent work in nonlinear mathematics, the idea at the heart of the book is truly important: even in vastly complicated interactive networks, a few simple rules can easily--if amazingly--lead to order and self-organised patterns and processes. This represents a major advance in understanding how the living world works. --Robert M. May, The Observer Stuart Kauffman's book. . .is a global representation of a new field, that will greatly enhance our physical understanding of Nature. It treats from a physical standpoint the processes of molecular selfordering, as biologists witness them in the living world, and it does so in a most original and authoritative way. A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. --Manfred Eigen, Max-Planck Institut fur Biophysikalische Chemie There are very few people in this world who ever ask the right questions of science, and they are the ones who affect its future most profoundly. Stuart Kauffman is one of these. Read this book. --Philip Anderson, Nobel Laureate, Dept. of Physics, Princeton University The conventional concept of Darwinian evolution views populations of organisms as randomly varying systems shaped to adaptation by the external force of natural selection. But Darwinian theory must be expanded to recognize other sources of order based on the internal genetic and developmental constraints of organisms and on the structural limits and possibilities of general physical laws. Stu Kauffman has been exploring these unorthodox sources of order for many years and has now produced an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. --Stephen Jay Gould, Harvard University Has there been time, since the origin of life on earth, for natural selection to produce the astonishing complexity of living organisms? Kauffman offers a new and unorthodox answer to this question. Given what we know about the way genes signal to one another, he argues that complexity can arise more readily than one would expect. I am not sure he is right, but I am sure that we should take his ideas seriously. --John Maynard Smith, University of Sussex Professor Kauffman's book is highly imaginative and provocative. --Lewis Wolpert, University College and Middlesex School of Medicine The facile claim that natural selection can accomplish every adaptive change fails to grapple with the problems posed by a highly structured system with its own laws of assembly and interaction. Stuart Kauffman's book, The Origins of Order, returns the problem of evolution to the central issue that evolutionists have been avoiding for too long, the problem of the evolution of a complex, organized system that we call, appropriately, an organism. Evolutionists had better take Kauffman's arguments seriously. --Richard C. Lewontin, Harvard University I rarely agree with Stuart Kauffman, but I always enjoy arguing with him. If you are interested in novel theories, buy this book--you will find lots of ideas worth wrestling with. --Leslie E. Orgel, The Salk Institute A big book with a big purpose. . .asks the question: What are the sources of the overwhelming and beautiful order which graces the living world? . . .the first book to be written by any of the complexity theorists themselves. . .a major work in the progression of biological theory. At the very least, Kauffman has made a persuasive case to have his bold hypothesis heard. --New Scientist Big, radical and exciting. . .our thinking about the origins of order and the processes of selection could be transformed. . .Kauffman is a serious biologist working at the creative edge of a new science, and his tightly argued book offers a bold and fascinating challenge to reductionist biology. --Sunday Independent Kauffman's whole book is a fertile and inventive ramification of ideas. . .characteristic originiality. .. . The dialogue initiated in this remarkable book will be with us for some time to come. --The Times Higher Education Supplement The material is presented in an ordered and detailed fashion, with extensive references to and applications from mathematics, physics, and molecular biology. Kauffman presents an intriguing work. An interesting and provocative work, well referenced. Recommended. --Choice A new way of looking at cellular and evolutionary process. . .comprehensive and sophisticated. It is a book designed to bring scientists up to speed with the theory of dynamical systems. For biologists, it is essential reading. They will be challenged by the theoretical structure of the book and by the possibility, brought alive in this splendid effort, that there is after all a view of life that is at once holistic and scientific. --Integrative Psychological and Behavioral Science An attempt to focus attention on new themes in developmental and evolutionary biology, while including Darwinism in a broader context. --Journal of Chemical Education Controversial. Kauffman has attacked orthodox biologists for ignoring the innate tendencies of complex systems to exhibit order spontaneously. Kauffman backs his claim with extensive mathematical models. --Paul Davies, The Manchester (UK) Guardian The style is heady, sententious and dangerously seductive, with an audible breathlessness throughout, brought on by the structural wonders visible in nonlinear dynamical systems. --Nature Stuart Kauffman. . .provides us with plenty of new ideas that can give rise to experimental tests and to new unexpected developments. . .I am convinced that complex evolutionary dynamics will become a central issue in future evolutionary biology and Stuart Kauffman will be among the pioneers in the field. . .buy the book and read it. --Bioessays A classic. Kauffman for the first time - atleast with such force and thoroughness - brings together selectionist and systems-theoretical notions of evolution into a single powerful agenda for the creation of life. . .an articulate and detailed text. . .a must for academic libraries. His writing style, however, is lucid and unencumbered by unnecessary jargon or formality. . .an essential reference in the field of evolutionary studies for many years to come. --World Futures: The Journal of General Evolution Few authors are more suited to take on such a task than is Stuart Kauffman, who is one of the pioneers in the modern renaissance of mathematical biology. We see here Kauffman's literate writing style and his joy in exposition. . .I applaud Stuart Kauffman for showing us some of what can be done. --Biophysical Journal A landmark event in this movement. . .Kauffman's work is awesome in its scope and execution. His writing is clear, lucid, even elegant, and he enriches every argument with examples, with supportive evidence and with helpful metaphors. . .Kauffman's overarching conclusion is likely to be controversial, even gratuitously so. Infact, Kauffman turns Darwinism on its head. --European Sociobiological Society Newsletter Impressive. . .magisterial. . .Rich as torte cake. --The Australian The book does not make easy reading, but the reader who spends the time will be rewarded. --Journal of the American Chemical Society

Author Information

Stuart Kauffman, M.D., is a MacArthur Fellow, and a philosopher, biologist, evolutionary theorist, and one of the founders of the discipline known as complexity.

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