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OverviewHydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning on the ground of an inclusive compilation of experimental H-bond energies and geometries. New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but inter-consistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond proton-transfer pathway. Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials. Full Product DetailsAuthor: Gastone Gilli (Full Professor of Physical Chemistry, Director of the Centre for Structural Diffractometry, University of Ferrara, Italy) , Paola Gilli (Department of Chemistry, University of Ferrara, Italy)Publisher: Oxford University Press Imprint: Oxford University Press Volume: 23 Dimensions: Width: 15.70cm , Height: 1.70cm , Length: 23.40cm Weight: 0.608kg ISBN: 9780199673476ISBN 10: 0199673470 Pages: 336 Publication Date: 11 April 2013 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsA real contribution to the field. Gautam R. Desiraju, University of Hyderabad This book should be required reading for biochemists as well as for anyone who designs or interprets empirical models that need to reproduce systems where H-bonding is important. A valuable contribution to our understanding of H-bonds. The Gillis should be commended for the considerable time and effort they must have spent on this endeavor. Journal of the American Chemical Society This book should be required reading for biochemists as well as for anyone who designs or interprets empirical models that need to reproduce systems where H-bonding is important. A valuable contribution to our understanding of H-bonds. The Gillis should be commended for the considerable time and effort they must have spent on this endeavor. * Journal of the American Chemical Society * A real contribution to the field. * Gautam R. Desiraju, University of Hyderabad * Author InformationProfessor Gastone Gilli Full Professor of Physical Chemistry and Director of the Centre for Structural Diffractometry University of Ferrara, Italy Dr Paola Gilli Researcher of Physical Chemistry University of Ferrara, Italy Tab Content 6Author Website:Countries AvailableAll regions |
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