Overview

The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

Full Product Details

Author:   D. S. Eggleston (Smithkline Beecham Parmaceuticals, Harlow, Essex, U.K.) ,  Catherine D. Prescott (SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, U.S.A.) ,  Neil D. Pearson (SmithKline Beecham Pharmaceuticals, Harlow, Esses, U.K.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 15.20cm , Height: 1.70cm , Length: 22.90cm
Weight:   0.240kg
ISBN:  

9780122332104

ISBN 10:   0122332105
Pages:   228
Publication Date:   19 December 1997
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Introduction. Overview: RNA as a Therapeutic Target for Bleomycin, S.M. Hecht. RNA: Chemistry, Structure and Interactions: Synthetic RNA Modification and Cross-linking Approaches towards the Structure of the Hairpin Ribozyme and the HIV-1 Tat Protein Interaction with TAR RNA, M.J. Gait, D.J. Earnshaw, M.A. Farrow, and N.A. Naryshkin. The Ribosome - The Universal Protein-synthesizing Machine, R. Brimacombe. tRNA Recognition by Aminoacyl-tRNA Synthetases, S. Cusack, A. Yaremchuk, and M. Tukalo. RNA-Protein Recognition During RNA Processing and Maturation, G. Varani. RNA as a Target/RNA as a Tool: Exploiting RNA: Potential Targets, Screens and Drug Development, C.D. Prescott, L. Hegg, K. Nurse, R. Gontarek, H. Li, V. Emerick, T. Sterner, M. Gress, G. Thom, S. Guth, and D. Rispoli. Structural Basis for Aminoglycoside Antibiotic Action, J.D. Puglisi. Protein-RNA Recognition in a Highly Conserved Ribosomal Domain Targeted by Thiazole Antibiotics, D.E. Draper. Rnase P and Its Substrate, L.A. Kirsebom. Interfering with Gene Function at the RNA Level with Oligoymes - the Development of New Tools and Therapeutics, B.S. Sproat, S.T. George, M. Ma, and A.R. Goldberg. Progress towards Therapeutic Application of SELEX-derived Aptamers, B. Polisky. Catalysis of Organic Reactions by RNA - Strategies for the Selection of Catalytic RNAs, A. Jaschke. Conclusions and Opportunities, B.W. Metcalf. Appendix: Abstracts of Posters. Index.

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