Overview

This work provides detailed knowledge about the molecular features of the laminins and describes the structure-function relationships and interactions that define their biologically active domains. Many of the discoveries concerning the tissue-specific laminins and the role of different laminins are addressed. By covering topics such as gene coding for laminins, genetic diseases affecting laminins, evolutionary aspects, embryonic development, apoptosis, neurite outgrowth and cancer, this study provides a basis for understanding the role of laminins in development and disease.

Full Product Details

Author:   Peter Ekblom (Uppsala University, Sweden) ,  R. Timpl (Max-Planck-Institut fur Biochemie, Martinsried, Germany)
Publisher:   Harwood-Academic Publishers
Imprint:   Harwood-Academic Publishers
Volume:   2
Dimensions:   Width: 17.10cm , Height: 2.20cm , Length: 23.00cm
Weight:   0.888kg
ISBN:  

9783718658077

ISBN 10:   3718658070
Pages:   321
Publication Date:   01 September 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Unknown
Availability:   Out of stock  

Table of Contents

Biosynthesis, tissue distribution and isolation of laminins; structure of laminins and their chain assembly; laminin genes - structure, regulation and mutations in disease; laminins of epidermal structures; binding of laminins to extracellular structures; binding of laminins to extracellular matrix components; integrin-mediated cellular interactions with laminins; non-integrin laminin receptors; laminin isoferms in development; basement membrane as a differentiation and survival factor; drosophila laminin; laminins during neurite growth and nerve regeneration; interaction of tumor cells with basement membranes and laminin-1; dystroglycan - a novel laminin receptor and its involvement in the pathogenesis of muscular dystrophies.

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Peter Ekblom (Uppsala University, Sweden) (Author) , R. Timpl (Max-Planck-Institut fur Biochemie, Martinsried, Germany)

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