Overview

I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo­ genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re­ search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten­ tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi­ potent, and we focused on the preimplantation embryo for the histo­ genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car­ cinomas in general were a caricature of the process of renewal of their normal counterpart.

Full Product Details

Author:   Francisco F Nogales ,  G.B. Pierce
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1993
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.581kg
ISBN:  

9783642778544

ISBN 10:   3642778542
Pages:   367
Publication Date:   08 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Comparative Development of the Mammalian Yolk Sac.- 2. Development of the Human Yolk Sac.- 3. Histology of the Secondary Human Yolk Sac with Special Reference to Hematopoiesis.- 4. Kinetics of Hematopoiesis in the Human Yolk Sac.- 5. Macrophages in the Human Yolk Sac.- 6. ?-Fetoprotein and Other Proteins in the Human Yolk Sac.- 7. Yolk Sac Abnormalities: A Clinical Review.- 8. Experimental Models of Injury in the Mammalian Yolk Sac.- 9. Ultrasonography of the Human Yolk Sac.- 10. Morphological Changes of the Secondary Human Yolk Sac in Early Pregnancy Wastage.- 11. Yolk Sac Carcinoma: History of the Concept and the Experimental Models.- 12. Immunohistochemical Markers of Yolk Sac Tumors.- 13. Pathology of Ovarian Yolk Sac Tumors.- 14. Clinical Features and Management of Gynecologic Yolk Sac Tumors.- 15. Pathology of Testicular Yolk Sac Tumors.- 16. Pathology of Extragonadal Yolk Sac Tumors.- 17. Unusual Patterns, Subtypes, and Differential Diagnosis of Gonadal Yolk Sac Tumors.- 18. Clinical Features and Management of Testicular and Extragonadal Yolk Sac Tumors.

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