Overview

Our understanding of the genetic and developmental mechanisms underlying scoliosis is rapidly evolving, this timely second edition of The Genetics and Development of Scoliosis is to provide researchers, clinicians, and students with the most current views in this field.  This volume brings together leaders in understanding congenital and idiopathic scoliosis to present the current state of research, and to compare the genetic etiology of these conditions, in order to identify potential shared developmental mechanisms. This book will summarize the recent advances in studies of spinal development and how disruptions during embryogenesis in embryonic segmentation can lead to congenital vertebral defects. In addition, recent reports of genetic loci predisposing patients to develop juvenile and adolescent idiopathic scoliosis will be presented, and key clinical features are reviewed. Finally, there will be discussion of how genetic heterogeneity and gene-environment interactions may contribute to congenital scoliosis and isolated vertebral malformations.

Full Product Details

Author:   Kenro Kusumi ,  Sally L. Dunwoodie
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2nd ed. 2018
Weight:   0.489kg
ISBN:  

9783319901480

ISBN 10:   3319901486
Pages:   199
Publication Date:   22 June 2018
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter1: Developmental and Functional Anatomy of the Spine.- Chapter2: Environmental Factors and Axial Skeletal Dysmorphogenesis.- Chapter3: Congenital Scoliosis and Segmentation Defects of the Vertebrae in the Genetic Clinic.- Chapter4: The Genetics Contributing to Disorders involving Congenital Scoliosis.- Chapter5: Animal Models of Idiopathic Scoliosis.- Chapter6: Current Understanding of Genetic Factors in Idiopathic Scoliosis.- Chapter7: Genetics and Functional Pathology of Idiopathic Scoliosis.- Chapter8: Adolescence and Scoliosis: Deciphering the Complex Biology of Puberty and Scoliosis.

Reviews

"""The book is aimed at researchers, clinicians, and students involved in the treatment of patients with idiopathic and congenital scoliosis. Orthopedic surgeons, rehabilitation specialists, clinical geneticists, and primary care providers in particular may find information about abnormal spinal curvatures of interest. ... Not many books are exclusively dedicated to specific genetic disorders such as this one. ... This is a well-done review that will be a useful consultation resource for clinicians."" (Luis F Escobar, Doody's Book Reviews, January 31, 2020)"

The book is aimed at researchers, clinicians, and students involved in the treatment of patients with idiopathic and congenital scoliosis. Orthopedic surgeons, rehabilitation specialists, clinical geneticists, and primary care providers in particular may find information about abnormal spinal curvatures of interest. ... Not many books are exclusively dedicated to specific genetic disorders such as this one. ... This is a well-done review that will be a useful consultation resource for clinicians. (Luis F Escobar, Doody's Book Reviews, January 31, 2020)

Author Information

Kenro Kusumi, Ph.D., is a Professor in the School of Life Sciences at Arizona State University.Dr. Kusumi’s current research focuses on genomic analysis of spinal development and regeneration, and their applications to developing novel therapies for scoliosis and other spinal disorders. Sally L. Dunwoodie, Ph.D., is a Professor at the University of New South Wales and Laboratory Head in the Developmental Biology and Stem Cell Division at the Victor Chang Cardiac Research Institute in Sydney. Dr. Dunwoodie's research focuses on identifying genetic and environmental factors that disrupt embryogenesis and cause birth defects.

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