Overview

This text chronicles the evolution of human gene therapy, illustrating how imaginative concepts shaped the development of technologies. It should be of interest to those interested in clinical medicine, biotechnology and the biology of gene transfer.

Full Product Details

Author:   Theodore Friedmann
Publisher:   Cold Spring Harbor Laboratory Press,U.S.
Imprint:   Cold Spring Harbor Laboratory Press,U.S.
Volume:   v. 36
Dimensions:   Width: 18.10cm , Height: 3.60cm , Length: 23.00cm
Weight:   0.957kg
ISBN:  

9780879695286

ISBN 10:   0879695285
Pages:   729
Publication Date:   11 December 1998
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

The origins, evolution and directions of human gene therapy; retroviral vectors; lentiviral vectors; structure and genetic organization of adenovirus vectors; adenovirus vectors; strategies to adapt adenoviral vectors for gene therapy applications - targeting and integration; adeno-associated viral vectors; gene-transfer tool - herpes simplex virus vectors; emerging viral vectors; advances in synthetic gene-delivery system techology; receptor-mediated gene delivery strategies; naked DNA gene transfer in mammalian cells; delivery systems and adjuvants for DNA vaccines; targets for gene therapy; the haemotopoietic system as a target for gene therapy; cancer immunotherapy; gene transfer and stem-cell transplantation; suicide genes - gene therapy applications using enzyme/prodrug strategies; the logic of anti-angiogenic gene therapy; apoptosis as a goal of cancer gene therapy; advances in gene therapy for HIV and other viral infections; progress toward gene therapy for nervous system diseases; targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides; human gene therapy - public policy and regulatory issues; ethical issues in human gene transfer research.

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