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OverviewThis book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Full Product DetailsAuthor: Joseph E. Alouf (Institute Pasteur de Lille, France) , Daniel Ladant (PhD, Director of Research at French CNRS (National Center for Scientific Research) and head of the Biochemistry of Macromolecular Interactions unit at Institut Pasteur, Paris, France) , Michel R. Popoff (CNR Anaerobies et Botulisme, Unite Bacteries anaerobies et Toxines, Institut Pasteur, FRANCE) , Joseph E. Alouf (Institute Pasteur de Lille, France)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Edition: 3rd edition Dimensions: Width: 21.60cm , Height: 4.50cm , Length: 27.90cm Weight: 2.640kg ISBN: 9780120884452ISBN 10: 0120884453 Pages: 1072 Publication Date: 20 December 2005 Audience: Professional and scholarly , Professional & Vocational Replaced By: 9780128001882 Format: Hardback Publisher's Status: Out of Print Availability: Out of stock  Table of ContentsIntroduction A 116-year story of bacterial protein toxins (1888-2004): From 'diphtheritic poison' to molecular toxinology Evolutionary aspects of toxin-producing bacteria Mobile genetic elements and pathogenicity islands encoding bacterial toxins Regulation systems of toxin expression Toxin secretion systems Intracellular trafficking of bacterial protein toxins Translocation of bacterial protein toxin into the cytosol Bacterial toxins and virulence factors targeting the actin cytoskeleton and intracellular junctions Bacterial toxins and mitochondria Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome machineries Toxin receptors Molecular, functional and evolutionary aspects of ADP-ribosylating toxins Diphtheria toxin Attack of the nervous system by clostridial toxins: Physical findings, cellular and molecular actions Uptake and transport of clostridial neurotoxins Bacillus anthracis toxins Large clostridial cytotoxins modifying small GTPases Bordetella protein toxins Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin The Shiga toxins: Properties and action on cells Helicobacter pylori vacuolating toxin Pasteurella multocida toxin Cytolethal distending toxins Pseudomonas aeruginosa toxins Escherichia coli heat- stable enterotoxin b Paradigms and classification of bacterial membrane -damaging toxins Membrane damaging and cytotoxic phospholipases Bacteroides fragilis toxins Structure and mode of action of RTX cytolysins Genetics and phylogeny of RTX cytolysins The family of two-component cytolysins of Serratia and other bacteria Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and delta-cytolysins) of Staphylococcus aureus Aerolysin and related Aeromonas toxins Clostridium septicum pore-forming alpha-toxin Clostridium perfringens epsilon toxin Repertoire and general features of the family of cholesterol-dependent cytolysins Comparative three-dimensional structure of cholesterol-dependent cytolysins Perfringolysin O and Intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysins Pneumolysin: structure, function and role in disease Listeriolysin Enterococcus faecalis cytolysin toxin Streptolysin S: one of the most potent and elusive of all bacterial toxins The group B streptococcal beta-haemolysin/cytolysin Haemolysins of Vibrio cholerae and other Vibrio species Clostridium perfringens enterotoxin Bacillus cereus enterotoxins, bi- and tri-component cytolysins and other haemolysins Uropathogenic Escherichia coli cytolysins Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins What are superantigens ? Staphylococcal superantigens and the diseases they cause Streptococcal superantigenic toxins Superantigenic toxin of Yersinia pseudotuberculosis Comparative three-dimensional structure of bacterial superantigenic toxins Induction and modulation of inflammatory networks by bacterial protein toxins Clostridial toxins in the pathogenesis of gas gangrene Staphylococcal exfoliative toxins Medical applications of botulinum neurotoxins Bacterial protein toxins as food poisons Engineering of bacterial toxins for research and medicine Engineered bacterial toxin vaccines and adjuvants Toxins as tools Bacterial protein toxins as biological weapons INDEXReviewsThe title of this book says it all - this volume is encyclopedic, thorough, and as complete as any book of this type could be. .This book is a piece de resistance. The editors are to be congratulated on producing a revised edition with vitality. They have successfully met all of the challenges posed in knitting diverse contributions together. The Comprehensive Sourcebook of Bacterial Protein Toxins will be an authoritative reference work for many years. Every medical school and university library must have a copy. For the individual purchaser, it will be a worthwhile investment and a treasure trove of information. - Cyril J. Smith, Trinity College Dublin, Ireland for CLINICAL INFECTIOUS DISEASES (Sept 2006) Doody's 3 Star Review: This book presents an overview of current approaches to protein structure prediction. Beginning with very basic concepts, there is a transition to modern methods with a strong (and logical) emphasis on computational approaches...This book offers a comprehensive introduction to the techniques commonly employed in [the] field...This is a concise, well written overview of the field. More technical manuals are available and there is a great deal of primary literature. Nonetheless, this book is of substantial value to younger scientists. - Eugene A Davidson, PhD, Georgetown University School of Medicine (2006) The title of this book says it all - this volume is encyclopedic, thorough, and as complete as any book of this type could be. .This book is a pi ce de r sistance. The editors are to be congratulated on producing a revised edition with vitality. They have successfully met all of the challenges posed in knitting diverse contributions together. The Comprehensive Sourcebook of Bacterial Protein Toxins will be an authoritative reference work for many years. Every medical school and university library must have a copy. For the individual purchaser, it will be a worthwhile investment and a treasure trove of information. - Cyril J. Smith, Trinity College Dublin, Ireland for CLINICAL INFECTIOUS DISEASES (Sept 2006) Doody's 3 Star Review: This book presents an overview of current approaches to protein structure prediction. Beginning with very basic concepts, there is a transition to modern methods with a strong (and logical) emphasis on computational approaches...This book offers a comprehensive introduction to the techniques commonly employed in [the] field...This is a concise, well written overview of the field. More technical manuals are available and there is a great deal of primary literature. Nonetheless, this book is of substantial value to younger scientists. - Eugene A Davidson, PhD, Georgetown University School of Medicine (2006) Author InformationJoseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. His 40-year research work relates to the field of bacterial protein toxins and immunology of infectious diseases. He is also the co-editor of several books. Tab Content 6Author Website:Countries AvailableAll regions |
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