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OverviewThis Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments. Full Product DetailsAuthor: Alberto J.L. Macario , Everly Conway de Macario , Francesco CappelloPublisher: Springer Imprint: Springer Edition: 2013 ed. Dimensions: Width: 15.50cm , Height: 0.80cm , Length: 23.50cm Weight: 2.117kg ISBN: 9789400746664ISBN 10: 9400746660 Pages: 116 Publication Date: 26 April 2013 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1. Introduction: What is this book about?; What the clinician and the pathologist must know about chaperonopathies; What the general public must know about chaperonopathies.- 2. Stress and anti-stress mechanisms.- 3. The chaperoning system.- 4. Location and function of chaperones.- 5. The chaperonopathies.- 6. Molecular features of chaperonopathies.- 7. Hsp-chaperone subpopulations and their chaperonopathies.- 8. Structural and hereditary chaperonopathies.- 9. Chaperonopathies and genetic polymorphisms: a. Chap eronopathies due to gene dysregulation; b. Chaperonopathies of the aged; c. Chaperonopathies by mistake; d. Chaperonopathies in disease pathogenesis.- 10. Chaperones as biomarkers.- 11. Chaperonotherapy.- 12. Conclusion.- BibliographyReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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