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OverviewThe science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease.These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments. Full Product DetailsAuthor: Craig M. Powell (Assistant Professor in the Neurology and Psychiatry departments, Graduate School of Biomedical Sciences at Southwestern Medical School) , Lisa M. Monteggia (Assistant Professor in the Psychiatry department, Graduate School of Biomedical Sciences at Southwestern Medical School)Publisher: Oxford University Press Inc Imprint: Oxford University Press Inc Dimensions: Width: 18.90cm , Height: 2.90cm , Length: 26.00cm Weight: 1.206kg ISBN: 9780199744312ISBN 10: 0199744319 Pages: 420 Publication Date: 27 December 2012 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of Contents1. Introduction Craig M. Powell & Lisa M. Monteggia 2. Autism and Autism Spectrum Disorders: Clinical Overview Lisa Joseph, Sarah Spence & Audrey 3. Neuroimaging in Autism Spectrum Disorders Human Imaging Mikle South, John D. Herrington, Sarah J. Patterson 4. An overview of the genetics of autism spectrum disorders Joseph D. Buxbaum 5. Rett syndrome: On Clinical and Genetic Features, and Experimental Models based on Mecp2 dysfunction Gaston Calfa, Alan K. Percy and Lucas Pozzo-Miller 6. Mecp2 Knockout in mouse models of Rett syndrome Megumi Adachi and Lisa M. Monteggia 7. Putting into perspective the use of the Fmr1 KO mouse as a model for autism spectrum disorder Richard Paylor 8. Molecular functions of the mammalian fragile X mental retardation protein: Insights into mental retardation and synaptic plasticity Claudia Bagni & Eric Klann 9. Tuberous Sclerosis and Autism Dan Ehninger and Alcino J. Silva 10. PTEN and autism with macrocephaly Craig M. Powell 11. SHANK gene family and autism Craig M. Powell 12. Smith-Lemli-Opitz Syndrome and Role of Cholesterol in Autism Geeta Sarphare, Ryan Lee, and Elaine Tierney 13. Angelman Syndrome Edwin J. Weeber 14. Neuroligins and neurexins: Bridging the synaptic cleft in autism Craig M. Powell & Antony A. Boucard 15. Alterations of the serotonin-melatonin pathway in autism spectrum disorders: Biological evidence and clinical consequences Cecile Pagan, Richard Delorme, Jean-Marie Launay, Thomas Bourgeron 16. CNTNAP2 and autism spectrum disorders Olga Penagarikano & Daniel H. Geschwind 17. Chromosome 15q11.2q13.3 Aneusomies and Autism Spectrum Disorders David J. Wu and Carolyn Schanen 18. Oxytocin and vasopressin: Mechanisms for potential sex differences observed in ASD C. Sue Carter & Suma Jacob 19. FOXP2: Linking language and autism Genevieve KonopkaReviewsThis fascinating new book written by leaders in the field is a must read for scientists and physicians interested in the autistic disorders. I highly recommend it. Doody's Notes, May 2013 Author InformationCraig M. Powell, M.D., Ph.D. is a Neurologist and Neuroscientist interested in the molecular, cellular, and circuit-level mechanisms underlying cognitive function and cognitive dysfunction in disorders such as autism and intellectual disability. Dr. Powell has been integrally involved in understanding brain abnormalities in genetic animal models of autism based on mutations in autism-associated genes such as SHANK3, neuroligins, neurexins, and PTEN. His work integrates multiple approaches to understanding how genetic mutations lead to altered neuronal function and altered circuit function to cause the behavioral symptoms of autism. His work has identified potential therapeutic targets for autism using such models. Lisa M. Monteggia, PhD is the Ginny and John Eulich Professor in Autism Spectrum Disorders, and Associate Professor of Psychiatry, at University of Texas Southwestern Medical Center in Dallas. Dr. Monteggia's research interests focus on the molecular and cellular basis of neural plasticity as it pertains to psychiatric disorders. She utilizes molecular, cellular, behavioral, biochemical and electrophysiological approaches to elucidate how specific genes may contribute to psychiatric disorders in animal models, specifically focusing on better understanding Rett Syndrome/Autism and depression. Once these mechanisms are understood, treatments can be developed to target specific molecular pathways for therapeutic advances. Tab Content 6Author Website:Countries AvailableAll regions |
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