Overview

What we now call 'deep venous thrombosis' (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives -- the haematological/biochemical -- come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, the authors show that the current consensus model is conceptually flawed.

Full Product Details

Author:   P. Colm Malone ,  Paul S. Agutter
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2008
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.528kg
ISBN:  

9789048176892

ISBN 10:   9048176891
Pages:   318
Publication Date:   19 October 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

to the Study of Deep Venous Thrombosis.- The Coagulation Cascade and the Consensus Model of DVT.- Hypercoagulability.- Historical Roots.- Coagulation and its Disorders: A History of Haematological Research.- Virchow and the Pathophysiological Tradition in the 19th Century.- The Pathophysiological Tradition after Virchow.- Interrupted Circulation: The ‘Stasis’ Hypothesis and the Significance of Venous Valves.- Underperfusion of Valve Pockets and the Initiation of DVT.- The Role of Endothelial Hypoxia in DVT.- The Valve Cusp Hypoxia Hypothesis.- Molecular Changes in the Hypoxic Endothelium.- Cadaver Clots or Agonal Thrombi?.

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