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OverviewATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book - that brings together state-of-the-art knowledge on ABC proteins in one volume - will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth. Full Product DetailsAuthor: Kenneth J Linton (Queen Mary Univ Of London, Uk) , I Barry Holland (Univ Paris-sud, France)Publisher: World Scientific Publishing Co Pte Ltd Imprint: World Scientific Publishing Co Pte Ltd Dimensions: Width: 15.70cm , Height: 2.80cm , Length: 23.10cm Weight: 0.885kg ISBN: 9789814280068ISBN 10: 9814280062 Pages: 480 Publication Date: 22 September 2011 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Awaiting stock  The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you. Table of ContentsStructure and Mechanism of ABC Transporters; ABCA1-Mediated HDL Formation; Bile Formation, the Enterohepatic Circulation and Cholestasis; Deciphering the Role of Human Efflux Proteins in Cellular and Tissue Permeability; The Photoreceptor ABC Transporter and Its Role in Inherited Retinal Degenerative Diseases; ABCs in Immunity - The Antigen Translocation Machinery; The ABCs of Mitochondrial Metabolic Disorders; The Role of ABCC Family Members for the Disposition of Endogenous Compounds and Drugs; ABC Transporter Mutations in Heritable Skin Diseases; CFTR, Elucidating the Basis and Influencing the Outcome of a Major Genetic Disease; Physiology and Pathology of ABCC8; Getting into the Peroxisome with the ABCD Family; ABC Transporters and Sterol Homeostasis; Hot Topics, including: Multidrug Transporters in Stem Cells and Cancer Stem Cells; Targeting Regulation of ABC Transporters; Nuclear Receptors involved in Regulating Bile Flow; Gene and Small Molecule Therapy for Cystic Fibrosis.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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