Overview

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.  This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.  Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of informationfor students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Full Product Details

Author:   Kewal K. Jain
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   3rd ed. 2021
Weight:   1.712kg
ISBN:  

9783030620820

ISBN 10:   3030620824
Pages:   744
Publication Date:   07 December 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface to the 3rd edition   1 Basic Aspects Definition of personalized medicine History of medical concepts relevant to personalized medicine Molecular biological basis of personalized medicine Basics technologies for developing personalized medicine ‘Omics’ and personalized medicine Conventional medicine versus personalized medicine Personalized medicine and evidence-based medicine Role of genetics in future approaches to healthcare Role of systems biology in personalized medicine Synthetic biology and development of personalized medicines Personalized digital medicine A personalized approach to environmental factors in disease Reclassification of diseases Translational science and personalized medicine Personalization of multimodal therapies   2 Molecular Diagnostics in Personalized Medicine Introduction Molecular diagnostic technologies                Sequencing Biochips and microarrays SNP genotyping Detection of copy number variations Study of rare variants in pinpointing disease-causing genes Optical Mapping Proteomics in molecular diagnosis Role of nanobiotechnology in molecular diagnostics Role of biosensors in personalized medicine Gene expression profiling Molecular imaging and personalized medicine Combination of diagnostics and therapeutics Point-of-care diagnosis Genetic testing for disease predisposition Combination of diagnostics with therapeutics Future of molecular diagnostics in personalized medicine   3 Role of Biomarkers in Personalized Medicine   4 Pharmacogenetics Basics of pharmacogenetics Role of molecular diagnostics in pharmacogenetics Role of pharmacogenetics in pharmaceutical industry Clinical implications of pharmacogenetics Limitations of pharmacogenetics Pharmacoepigenomics vs pharmacogenetics in drug safety Future role of pharmacogenetics in personalized medicine   5 Pharmacogenomics Introduction Basics of pharmacogenomics Pharmacogenomics and drug discovery Pharmacogenomics and clinical trials Pharmacogenomic aspects of major therapeutic areas Current status and future prospects of pharmacogenomics   6 Role of Pharmacoproteomics Basics of proteomics Proteomic approaches to the study of pathophysiology of diseases Proteomic technologies for drug discovery and development Applications of pharmacoproteomics in personalized medicine   7 Role of Metabolomics in Personalized Medicine Metabolomics and metabonomics Metabolomics bridges the gap between genotype and phenotype Metabolomics, biomarkers and personalized medicine Metabolomic technologies Pharmacometabonomics Metabonomic technologies for toxicology studies Metabonomics/metabolomics and personalized nutrition Metabolomics for personalized medicine   8 Role of Nanobiotechnology in Development of Personalized Medicine   9 Personalized Biological Therapies Introduction Recombinant human proteins Therapeutic monoclonal antibodies Cell therapy Gene therapy Personalized vaccines Antisense therapy   10 Personalized Non-pharmacological Therapies Introduction Acupuncture Personalized hyperbaric oxygen therapy Personalized nutrition Personalized physical exercise Personalized surgery   11 Personalized Therapy of Cancer   12 Personalized Therapy of Neurological Disorders   13 Personalized Therapy of Psychiatric Disorders   14 Personalized Therapy of Cardiovascular Disorders   15 Personalized Therapy of Pulmonary Disorders         16 Personalized Therapy Infectious Diseases   17 Personalized Approaches in Immunology   18 Personalized Management of Genetic Disorders   19 Personalized Management of Miscellaneous Disorders Personalized management of DNA repair disorders Personalized preventive medicine Personalized management of ophthalmic disorders          Personalized management of skin disorders Personalized urology Personalized therapy of rheumatoid arthritis Personalized management of obesity Personalized management of diabetes Management of genetic disorders Personalized management of gastrointestinal disorders Personalized approaches to improve organ transplantation Personalized approaches to addiction Personalized geriatrics Personalized pediatrics Personalized nephrology Personalized gynecology   20 Development of Personalized Medicine Introduction Non-genomic factors in the development of personalized medicine Players in the development of personalized medicine Role of genetic banking systems and databases Role of bioinformatics in development of personalized medicine Integration of technologies for personalized medicine Global scope of personalized medicine Advantages of personalized medicine Limitations of personalized medicine Future of personalized medicine   21 Ethical Aspects of Personalized Medicine   22 Legal Aspects of Personalized Medicine   23 Regulatory Aspects of Personalized Medicine FDA and personalized medicine FDA and molecular diagnostics in relation to personalized medicine Regulatory aspects of pharmacogenetics Regulation of direct-to-consumer genetic testing FDA and pharmacogenomics FDA and predictive medicine   24 Economics of Personalized Medicine   25 Future of Personalized Medicine

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Prof. K. K. Jain MD, FRACS, FFPM Jain PharmaBiotech Blaesiring 7 CH-4057 Basel, Switzerland

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