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OverviewTaxol, originally derived from the North American Yew tree in 1971, is well-known worldwide as a powerful anticancer agent. Mechanistically, it has a unique microtubule stabilizing activity, and was clinically developed as a therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C., USA.In this volume, the authors provide an authoritative account of the taxoids. it covers their production and biosynthesis - from commercial cultivation to plant tissue culture methods - describes taxoid chemistry, the analytical methods for identifying their structure and the pharmacological and pre-clinical aspects important in investigating their therapeutic actions.It presents a thorough review of the scientific literature, including data from scientists currently engaged in taxoid research, and will be of significant value to researchers and others who wish to gain a practical perspective on taxoid research and development. Full Product DetailsAuthor: Hideji Itokawa , Kuo-Hsiung LeePublisher: Taylor & Francis Ltd Imprint: CRC Press Dimensions: Width: 17.80cm , Height: 3.10cm , Length: 25.40cm Weight: 0.970kg ISBN: 9780415298377ISBN 10: 0415298377 Pages: 472 Publication Date: 13 February 2003 Audience: Professional and scholarly , Professional and scholarly , Professional & Vocational , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1. Introduction 2. Biosynthesis of Taxoids 3. Taxoids Occurring in the genus Taxus 4. Physical Methods for Identifying the Structures of Taxoids 5. Plant Tissue Culture of Taxoids 6. The Commercial Cultivation of Taxus Species and Production of Taxoids 7. Analytical Aspects of Taxoids 8. Chemistry of Taxol and Related Taxoids 9. Total Synthesis of Taxoids 10. Structure-Activity Relationships of Taxoids 11. Pre-clinical and Clinical Investigation of the Taxanes 12. Paclitaxel Content of Yews in IrelandReviewsAuthor InformationHideji Itokawa, Kuo-Hsiung Lee Tab Content 6Author Website:Countries AvailableAll regions |
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