Overview

This volume brings together all aspects of TAXOL research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.

Full Product Details

Author:   Matthew Suffness ,  Mannfred A. Hollinger (University of California, Davis, USA) ,  Mannfred A. Hollinger (University of California, Davis, USA) ,  Monroe E. Wall
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   22
Dimensions:   Width: 17.80cm , Height: 3.00cm , Length: 25.40cm
Weight:   0.970kg
ISBN:  

9780849383823

ISBN 10:   084938382
Pages:   436
Publication Date:   25 May 1995
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction Discovery and Development of TAXOL (R), M. Suffness and M.E. Wall Yew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr. Supply of TAXOL (R) Taxus for TAXOL (R) and Taxoids, E.M. Croom, Jr. Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. Shuler Semisynthesis of TAXOL (R) and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas Boatman Toward the Total Synthesis of TAXOL (R) and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. Shuker Biology of TAXOL (R) Biosynthesis of TAXOL (R), H.G. Floss and U. Mocek Preclinical Antitumor Activity of Taxanes, W.C. Rose Biopharmaceutics of Paclitaxel (TAXOL (R)): Formulation, Activity, and Pharmacokinetics, R.M. Straubinger The Use of TAXOL (R) in Cell Biology, R.B. Vallee Chemistry of TAXOL (R) Detection and Isolation, K.M. Snader Natural Taxoids: Structure and Chemistry, D.G.I. Kingston The Medicinal Chemistry of TAXOL (R) , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. Park Clinical Studies TAXOL (R) : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. Blaylock Index

Reviews

...a marvelous job of assembling a cast of contributors who have excelled in bringing to full light the developmental hurdles a natural product can face en route to market and in highlighting the efforts and research strategies employed in attempts to surmount those barriers. -Dolatrai M. Vyas, J. Nat. Prod., 1996, 59, 216-218

... a marvelous job of assembling a cast of contributors who have excelled in bringing to full light the developmental hurdles a natural product can face en route to market and in highlighting the efforts and research strategies employed in attempts to surmount those barriers. -Dolatrai M. Vyas, J. Nat. Prod., 1996, 59, 216-218

Author Information

Suffness\, Matthew

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