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OverviewInappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway. Full Product DetailsAuthor: Kathleen H. Goss , Michael KahnPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2011 ed. Dimensions: Width: 15.50cm , Height: 1.30cm , Length: 23.50cm Weight: 0.391kg ISBN: 9781489981646ISBN 10: 1489981640 Pages: 240 Publication Date: 13 October 2014 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsAn Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution.- Wnt Signaling in Stem Cells.- Crosstalk of the Wnt Signaling Pathway.- Dysregulation of the WNT Pathway in Solid Tumors.- WNT/b-catenin Signaling in Leukemia.- Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer.- Targeting Wnt Signalling in Cancer.- Inhibiting the Wnt Signaling Pathway with Small Molecules.- Targeting of Wnt Signaling Inside the Nucleus.-ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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