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Author:   Jian Zhang (Shanghai Jiao Tong University, China)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
ISBN:  

9783527353606

ISBN 10:   3527353607
Pages:   432
Publication Date:   12 November 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

1. Overview of protein-protein interaction (PPI) systems 2. Overview of drug discovery targeting PPI systems 3. Bioluminescence resonance energy transfer (BRET) assay for PPI study 4. Mass spectrometry (MS) for PPI study 5. Proximity ligation assay (PLA) for PPI study 6. Surface plasma resonance (SPR) assay for PPI study 7. Computational methods for PPI study 8. Peptidomimetics for PPI drug discovery 9. AApeptides for PPI drug discovery 10. Stapled peptides for PPI drug discovery 11. Cyclic peptides for PPI drug discovery 12. PPI drug discovery targeting B cell lymphoma (BCL) family 13. PPI drug discovery targeting MDM2-p53 14. PPI drug discovery targeting APC-Asef 15. Computational methods applied to drug discovery for PPI systems 16. Allosteric modulation of PPI systems for drug discovery 17. Current Challenges and Future Directions

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Author Information

Jian Zhang is a Distinguished Professor and Doctoral Supervisor at School of Medicine, Shanghai Jiao Tong University, China. He is also the Director of the Medicinal Bioinformatics Center. His fields of research include first-in-class drug design and chemical biology, mainly pertaining to protein-protein interactions and allostery and their application in drug discovery. He received a BM degree in Pharmacology from Peking University and a PhD from Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

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