Overview

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development. It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy It highlights recent metallo-drug developments targeting COVID-19 It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

Full Product Details

Author:   Etelka Farkas (University of Debrecen) ,  Celine J. Marmion (RCSI University of Medicine and Health Sciences)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.800kg
ISBN:  

9781032223308

ISBN 10:   1032223308
Pages:   370
Publication Date:   15 May 2023
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli by Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol. Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy by Dmytro Havrylyuk, Austin Hachey, and Edith Glazer. Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes by Andrea Erxleben. Chapter 4 Transition Metal-Based Antiviral Agents against SARS-CoV-2 and Other Pathogenic Viruses by Maria Gil-Moles and Ingo Ott. Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs by Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi, and Luigi Messori . Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug-Resistant Bacteria by Andris Evans and Kevin Kavanagh. Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases by Dinorah Gambino and Lucía Otero. Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment by Sigridur G. Suman. Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells by Johannes Karges and Nils Metzler-Nolte.Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine by Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun. Chapter 11 Metal-Based Nanoclusters for Biomedical Applications by Edit Csapó. Chapter 12 Radiometals in Molecular Imaging and Therapy by Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikołajczak.

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Etelka Farkas, Celine J. Marmion

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