Overview

Cancer is a complex and heterogeneous (systematic) disease that exhibits high levels of robustness against various therapeutic interventions. Due to the complex, heterogeneous, and evolving nature of cancer, it is essential for a system-oriented view to be adopted in order to understand the pathogenic mechanism of cancer which will eventually lead to the drug discovery and treatment of patients. This book not only provides new insights from system modeling and large scale experimental data, but also will allow the reader to perceive the systematic characteristics of cancer under some micro-environments. Based on the systems biology method and genome-wide high throughput data, the book presents the PPI network, gene regulatory network and epigenetic network as an integrated genetic and epigenetic cellular network of lung cancer, bladder cancer, thyroid cancer, colorectal cancer, and liver cancer to investigate their core signaling pathways of the carcinogenesis process to identify their corresponding significant carcinogenic biomarkers as drug targets for systems drug discovery and design. Consequently, the book presents the design of a multiple-molecule drug that can target these biomarkers for the therapeutic treatment of cancer with fewer side effects.

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9781527569744

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Dr Bor-Sen Chen received his PhD from the University of Southern California in 1982. He is the Tsing Hua Distinguished Chair Professor in the Department of Electrical Engineering and Computer Science of National Tsing Hua University, Taiwan. He has received the Distinguished Research Award from the National Science Council of Taiwan four times, and has published more than 300 papers. He is a National Chair Professor of the Ministry of Education, Taiwan, and his current research interests include control engineering, signal processing and systems biology.

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